基于血管生成素的药物研发

发布时间：2018-04-12 18:45

本文选题：血管生成素 + 血管生成　；参考：《中国生物化学与分子生物学报》2015年12期

【摘要】：血管生成素(angiogenin,ANG)在伤口愈合、月经周期、妊娠、胚胎发育、先天性免疫、细胞应激保护和维持机体稳态等生理病理过程,特别是肿瘤的生存与进展、神经细胞的存活和生长中扮演着重要角色,是药物研发的重要靶点.本文综述了ANG在功能上的特殊性及其药物研发潜力.在肿瘤中,ANG扮演促进肿瘤细胞增生和促进血管生成的双重角色,且是其它血管生成因子如血管内皮生长因子(vascular endothelial growth factor,VEGF)、酸性成纤维生长因子(acidic fibroblast growth factor,a FGF)、碱性成纤维生长因子(basic fibroblast growth factor,b FGF)和表皮生长因子(epidermal growth factor,EGF)发挥作用的必需准许因子.ANG的抗肿瘤治疗较之目前常用的针对单一血管生成因子的抑制剂更有效,具有良好的药物研发和临床运用前景.由于ANG通过核转位促进r RNA转录是发挥促进肿瘤细胞增生和血管生成活性所必须的,因此,它的核转位抑制剂如新霉胺,将有望首先获得抗肿瘤临床应用.另外,业已证明重组ANG能促进体内外运动神经元的存活,且可明显改善肌萎缩侧索硬化症(amyotrophic lateral sclerosi,ALS)模型小鼠的行为,其在神经退行性疾病治疗方面也将有良好的研发前景.
[Abstract]:Angiopoietin (angiogenin, ANG) in wound healing, menstrual cycle, pregnancy, embryo development, innate immunity, cellular stress protection and maintaining the homeostasis of body physiological and pathological processes, especially the survival and progress of tumor, survival and plays an important role in the growth of nerve cells, are important targets for drug development. This paper reviews the ANG function on the particularity and drug development potential. In tumors, ANG plays a dual role to promote tumor cell proliferation and angiogenesis, and other angiogenic factors such as vascular endothelial growth factor (vascular endothelial, growth factor, VEGF), acidic fibroblast growth factor (acidic fibroblast growth factor A, FGF), basic fibroblast growth factor (basic fibroblast growth factor, B FGF) and epidermal growth factor (epidermal growth, factor, EGF) play the role of the necessary licensing factor.ANG Anti tumor treatment than for the single angiogenesis inhibitors commonly used more effective, with good drug development and clinical application prospect. Because ANG r promote RNA transcription is required to promote tumor cell proliferation andangiogenesis activity, the nuclear translocation of the nuclear translocation of its inhibitors such as pyrimethanil, is expected to the first clinical application of anti tumor. In addition, it has been proved that the recombinant ANG could promote the survival of motor neurons in vitro and in vivo, and can significantly improve the amyotrophic lateral sclerosis (amyotrophic lateral, sclerosi, ALS) model mice, in the treatment of neurodegenerative diseases will also have good prospects for development.

【作者单位】：华中科技大学同济医学院药学院;
【基金】：国家十二五重大新药创制专项资金资助(No.2012ZX09103101-047)~~
【分类号】：R94

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