天然阿洛糖苷的研究进展

发布时间：2018-04-14 11:29

本文选题：糖苷 + 黄酮阿洛糖苷　；参考：《药学学报》2017年03期

【摘要】：天然糖苷类化合物的药理活性与不同糖基之间有着密切的关系,通过糖基化可以改变整个糖苷分子的构象,提高其水溶性,增强其生物活性,甚至改变其药代特性和药理作用机制等。与生物体内常见的D-葡萄糖相比,D-阿洛糖是D-葡萄糖的C-3差向异构体,单糖本身就是一种低能量、不被消化的安全无毒的食糖替代品,已在膳食、保健、医药等领域发挥着重要的生理功能。但自然界中D-阿洛糖绝大部分以稀有的糖苷形式存在,与常见的糖苷如葡萄糖苷、鼠李糖苷等一样,也具有广泛的生物活性。本文主要简述从植物中分离鉴定的不同类型的阿洛糖苷类化合物,还基于文献对其抗肿瘤、抗糖尿病等多种药理活性及其不同糖基取代的构效关系进行综合分析,为基于糖苷类化合物的新药发现和药物设计提供研究思路。
[Abstract]:The pharmacological activities of natural glycosides have a close relationship with different glycosyl groups. Glycosylation can change the conformation of the whole glycoside molecule, improve its water solubility and enhance its biological activity.Even change its pharmacokinetic characteristic and pharmacological action mechanism and so on.Compared with D- glucose, a C-3 isoform of D- glucose, monosaccharide itself is a low energy, non-digested, safe, nontoxic alternative to sugar, already in the diet and health care.Medicine and other fields play an important physiological function.However, most of D- aroses in nature exist in the form of rare glycosides, which have a wide range of biological activities as common glycosides such as glucosides and rhamnosides.In this paper, the different types of aloglycoside compounds isolated from plants were reviewed, and their pharmacological activities, such as anti-tumor, anti-diabetes, and structure-activity relationships of different glycosyl substitutions were also comprehensively analyzed based on the literature.To provide research ideas for new drug discovery and drug design based on glycoside compounds.
【作者单位】：山东中医药大学药学院;中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室;
【基金】：中国医学科学院医学与健康科技创新工程项目(2016-I2M-3-012) 北京协和医学院“协和青年基金”项目(3332016057)
【分类号】：R96

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