HPLC-ESI-MSn法鉴定乳糖酸阿奇霉素中的有关物质

发布时间：2018-04-14 16:17

本文选题：乳糖酸阿奇霉素 + 有关物质　；参考：《黑龙江畜牧兽医》2017年13期

【摘要】：正阿奇霉素~([1])是一种新型的大环内酯类抗生素,广泛用于临床,适用于敏感菌所致的呼吸道、皮肤软组织感染和衣原体所致的性传播性疾病。具有抗菌谱广、不良反应小、临床应用广泛等优点~([2-3])。目前,国内已有多家药厂生产该产品及其制剂,因此制剂中有关物质的含量测定和质量控制具有必要性。试验采用HPLC-ESI-MSn联用~([4-8])的方法检测了一批乳糖酸阿奇霉素中的有关物质,并使用USP
[Abstract]:Azithromycin ([1]) is a new macrolide antibiotic, which is widely used in clinic. It is suitable for respiratory tract, skin soft tissue infection and sexually transmitted diseases caused by chlamydia.It has the advantages of wide antibacterial spectrum, small adverse reaction and wide clinical application ([2-3]).At present, many pharmaceutical factories have produced the product and its preparation, so it is necessary to determine the content and quality control of the related substances in the preparation.The related substances in azithromycin lactate were determined by HPLC-ESI-MSn and USP.
【作者单位】：江苏农牧科技职业学院动物药学院;
【分类号】：O657;R927.2

【相似文献】