治疗药物监测的方法学研究进展

发布时间：2018-04-16 05:30

本文选题：治疗药物监测 + 方法学　；参考：《中国医药科学》2016年08期

【摘要】：治疗药物监测(TDM)指的是在转向药学技术服务,保障患者使用药物安全的前提之下逐渐发展起来。在临床当中,因为人体差异以及其他相关因素,患者通过相同途径采取相同剂量药物以后,临床治疗反应却是存在较大差异。治疗药物监测就是利用定量分析生物样本当中的药物以及代谢产物浓度,正确指导临床使用药物,进而保证使用药物具有安全有效性。群体药动学方法是将药动学参数与疗效联系在一起,有利于正确指导个体化治疗,是治疗药物监测的主要工具。LC-MS在TDM工作当中的作用日趋重要。有限采样法通过有限点的血药浓度值对药物暴露量给予准确估算,进而使TDM更加经济适应,可以在临床当中广泛应用,同时方法学研究的不断进步对TDM的工作发展起到良好的促进作用。
[Abstract]:Therapeutic drug monitoring (TDM) refers to the gradual development under the premise of switching to pharmaceutical technical services to ensure the safety of drug use by patients.In clinic, because of the difference of human body and other related factors, there is great difference in the clinical treatment response after the patients take the same dose of drugs through the same way.Therapeutic drug monitoring is to use quantitative analysis of the concentration of drugs and metabolites in biological samples, correctly guide clinical use of drugs, and then ensure the safety and effectiveness of drug use.The group pharmacokinetics method is to link the pharmacokinetic parameters with the curative effect and is helpful to guide the individualized treatment correctly. LC-MS is the main tool of therapeutic drug monitoring. LC-MS plays an increasingly important role in the work of TDM.The limited sampling method can accurately estimate the drug exposure through the blood concentration of a limited point, thus making TDM more economical and can be widely used in clinical practice.At the same time, the continuous progress of methodological research plays a good role in promoting the development of TDM.
【作者单位】：呼和浩特市第二医院;
【分类号】：R95

【相似文献】