老年患者使用利奈唑胺的临床评价及不良反应监测

发布时间：2018-04-17 22:09

本文选题：利奈唑胺 + 老年患者　；参考：《中国新药杂志》2017年11期

【摘要】：目的:综合评价某综合教学医院老年住院患者使用利奈唑胺的临床合理性及其疗效和安全性。方法:采用回顾性研究方法,选取广州市某三甲医院2015年1月—2015年12月使用利奈唑胺注射剂或片剂的老年患者病例,根据药品说明书和相关指南,分析利奈唑胺的应用情况,并统计有效率及不良反应发生率。结果:共纳入有效病例55例(65~94岁),评价结果合理的有45例(81.81%),不合理的有10例(18.18%);治疗结果痊愈28例(50.91%),显效14例(25.45%),进步5例(9.09%),无效8例(14.54%)。用药后出现不良反应的有21例(38.18%),其中血小板减少19例(34.55%),白细胞减少4例(7.27%),血红蛋白减少3例(5.45%),恶心、呕吐3例(5.45%),腹泻2例(3.64%),皮疹1例(1.82%),乳酸性酸中毒1例(1.82%)。ICU患者血小板减少症的发生率明显高于非ICU患者(P=0.038),但不同剂型间的发生率无明显差异(P=0.512)。结论:利奈唑胺治疗老年患者革兰阳性球菌感染的疗效较好,但发生血小板减少的比例较高,尤其是ICU患者,值得临床关注。
[Abstract]:Objective: to evaluate the clinical rationality, efficacy and safety of the use of linazolamide in elderly inpatients in a general teaching hospital.Methods: a retrospective study was conducted to analyze the use of linazolamide in elderly patients who were treated with linazolamide injection or tablet from January 2015 to December 2015 in a third Class A Hospital in Guangzhou.The effective rate and the incidence of adverse reactions were counted.Results: a total of 55 cases were included in the study, 45 cases with reasonable evaluation results were 81.81 and 10 cases were unreasonable, 28 cases were cured, 14 cases showed remarkable effect, 5 cases improved 9.09 cases, and 8 cases had no effect on 14.544.Results: a total of 55 cases of effective cases were included, 45 cases of which were evaluated reasonably, and 10 cases of them were not reasonable, 28 cases were cured, 14 cases showed remarkable effect, 5 cases showed improvement of 9.09%, and 8 cases had no effect.Among them, 19 cases had thrombocytopenia (34.55%), 4 cases had leukopenia (7.27%), and 3 cases had hemoglobin reduction (5.45%).The incidence of thrombocytopenia in 3 patients with vomiting, 2 with diarrhea, 1.82 with rashes and 1.82 with lactic acidosis was significantly higher than that with P0. 038 in non ICU patients, but there was no significant difference in the incidence of P0. 51212 among different dosage forms.Conclusion: the efficacy of linazolamide in the treatment of Gram-positive cocci infection in elderly patients is better, but the proportion of thrombocytopenia is higher, especially in ICU patients, which deserves clinical attention.
【作者单位】：中山大学附属第一医院药学部;中山大学药学院;中山大学中山医学院药理学教研室;
【分类号】：R978

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