溴甲纳曲酮的合成

发布时间：2018-04-17 22:39

  本文选题：溴甲纳曲酮 + 季N-烷基吗啡喃生物碱盐　； 参考：《光谱实验室》2013年04期

【摘要】：溴甲纳曲酮可经过两步化学反应而获得,以盐酸纳曲酮为起始原料,经过氨水游离成游离纳曲酮碱,再与溴甲烷反应制备季N-烷基吗啡喃生物碱盐的粗品,粗品经过特殊精制手段达到除去常规精制方法难以除去的杂质,两个反应操作均较简易,本文献的特色点是反应路线比较简单,合成制备季N-烷基吗啡喃生物碱盐方法新颖,避开专利中的常规制备方法。除此之外,通过该粗品精致方案,能获得更少杂质的主产品,解决杂质限度难以低于千分之一的难题。
[Abstract]:Bromo-naltrexone can be obtained by two-step chemical reaction. Naltrexone hydrochloride is used as the starting material, free naltrexone alkaloids are dissociated through ammonia water, and then reacted with methyl bromide to prepare crude N-alkyl morphine alkaloids of quaternary N-alkyl morphine alkaloids.The crude product was purified by special means to remove impurity which is difficult to be removed by conventional refining method. The two reaction operations are both relatively simple. The characteristic point of this document is that the reaction route is relatively simple, and the method of preparing quaternary N-alkyl morphine alkaloid alkaloid salt is novel.Avoid conventional preparation methods in patents.In addition, through this refined coarse product, the main product with less impurity can be obtained, and the impurity limit is difficult to be lower than 1/1000.
【作者单位】： 重庆医科大学药学院;
【分类号】：TQ463
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本文编号：1765643