体外模型在药源性肾毒性评价中的研究进展

发布时间：2018-04-18 19:51

本文选题：肾毒性 + 体外模型　；参考：《中国新药杂志》2017年15期

【摘要】：由于肾毒性物质的靶器官选择性,药物诱导的肾毒性是目前新药开发和临床应用中存在的重要问题,高通量肾毒性体外评价模型可以提高大量化合物的筛选效率,节约时间和成本,已经逐渐成为肾毒性研究的主要研究方法。虽然肾毒性体外评价模型的研究热度不断升温,但由于肾毒性的特异性,仍未能建立标准的体外评价模型。目前,肾毒性体外评价的研究主要基于传统的2D细胞模型,3D细胞模型尚在初级阶段。本文对近年来高通量肾毒性体外评价模型的研究进展做一综述。
[Abstract]:Because of the target organ selectivity of nephrotoxic substances, drug induced nephrotoxicity is an important problem in the development and clinical application of new drugs. The in vitro evaluation model of high throughput nephrotoxicity can improve the screening efficiency of a large number of compounds.Saving time and cost has gradually become the main research method of nephrotoxicity research.Although the research heat of nephrotoxicity in vitro evaluation model is increasing, due to the specificity of nephrotoxicity, it is still unable to establish a standard in vitro evaluation model.At present, the in vitro evaluation of nephrotoxicity is mainly based on 2D cell model and 3D cell model.In this paper, the research progress of in vitro evaluation model of high-throughput nephrotoxicity in vitro was reviewed.
【作者单位】：中国医学科学院北京协和医学院;中国食品药品检定研究院;
【基金】：国家“重大新药创制”科技重大专项资助项目——符合中药特点的有毒中药安全性评价关键技术研究(2015ZX09501004-002)
【分类号】：R96

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