注射用长效避孕给药系统研究进展

发布时间：2018-04-19 03:24

本文选题：注射给药 + 长效避孕　；参考：《中国新药杂志》2016年03期

【摘要】：注射用长效避孕给药系统可维持避孕药恒定的血药浓度,精准控制药物持续释放几周甚至数月,从而大幅度减少给药次数,能较好解决目前临床上其他避孕制剂的续用率和依从性问题,为育龄女性提供一种相对安全、高效和简便的避孕方式。但目前相关上市产品有限,有待进一步开发新产品以满足各种避孕需求。按不同给药系统,长效避孕注射剂可分为油溶液、微晶混悬剂、微球和原位凝胶4类。经系统的文献调研,本文对各给药系统在避孕方面的研究进展作一综述,包括它们在研发阶段和临床应用中的特点,并总结归纳出开发长效避孕注射剂所面临的挑战。
[Abstract]:The long-acting contraceptive delivery system for injection can maintain a constant blood concentration of the contraceptive pill and accurately control the release of the drug for several weeks or even months, thereby dramatically reducing the number of doses.It can solve the problem of continuous use rate and compliance of other contraceptive preparations in clinic and provide a relatively safe, efficient and simple contraceptive method for women of reproductive age.However, the related products are limited and need to be further developed to meet various contraceptive needs.According to different drug delivery systems, long-acting contraceptive injection can be divided into four categories: oil solution, microcrystalline suspension, microsphere and in situ gel.Based on the systematic literature investigation, this paper reviews the research progress of the drug delivery systems on contraception, including their characteristics in the research and development stage and clinical application, and summarizes the challenges faced by the development of long-acting contraceptive injections.
【作者单位】：上海市计划生育科学研究所国家人口和计划生育委员会计划生育药具重点实验室上海生殖健康药具工程技术研究中心;广西中医药大学药学院;
【基金】：美国国家健康国际组织(FHI 360)资助项目(0647.0007/996345) 国家“十二五国家科技支撑”计划(2012BAI31B02)
【分类号】：R979.21

【相似文献】