克班宁透皮贴剂的制备及其体外经皮渗透实验研究

发布时间：2018-04-20 14:07

本文选题：克班宁 + 透皮贴剂　；参考：《中国新药杂志》2017年21期

【摘要】：目的:制备克班宁透皮贴剂,筛选促渗剂并考察其体外经皮渗透作用。方法:以初黏力和持黏力为指标进行贴剂基质处方的正交试验。采用改良的FRANZ扩散池,以累积渗透量和增渗系数为指标,考察1%,3%,5%,7%和10%的氮酮和丁香挥发油对克班宁透皮贴剂经小鼠皮肤的促渗作用,并用裸鼠进行验证。结果:优选的贴剂处方为丁二酸0.15 g,Eudragit EPO 2 g,邻苯二甲酸二乙酯0.8 g,甘油0.3 g。1%氮酮组和3%丁香挥发油的Q48分别为(0.691 5±0.541 8)和(0.805 1±0.435 4)mg·cm-2,增渗系数分别为1.89和2.15。结论:在优选处方下制备的贴剂黏附力适宜;3%丁香挥发油能显著提高克班宁在贴剂中的渗透量。
[Abstract]:Aim: to prepare kipanning transdermal patch, to screen permeation enhancer and to investigate its transdermal permeation in vitro. Methods: the orthogonal test of the base formulation of patch was carried out with the index of initial viscosity and holding force. An improved FRANZ diffusion cell was used to investigate the effects of 5% and 10% azone and 10% essential oil on the permeation of kipanning through the skin of mice, taking the cumulative permeation capacity and the permeability coefficient as the indexes, and to verify the effect of 1% and 10% of azone and eugenin essential oil on the permeation of mice skin. Results: the optimal formula was 0.15g Eudragit EPO 2 g, diethyl phthalate 0.8 g, glycerol 0.3 g 路1% azone group and 3% eugenol volatile oil Q48 was 0.691 5 卤0.541 8) and 0.8051 卤0.435 4)mg cm-2, respectively. The permeability enhancement coefficients were 1.89 and 2.15, respectively. Conclusion: the adhesive force of the patch prepared under the optimized prescription is suitable for 3% clove essential oil, which can significantly increase the osmotic capacity of kabanin in the patch.
【作者单位】：云南中医学院;
【基金】：国家自然科学基金资助项目(81260651,81673682)
【分类号】：R943

【相似文献】