头孢他啶用药频度与6种主要革兰阴性细菌耐药相关性的分析

发布时间：2018-04-21 13:49

本文选题：头孢他啶 + 用药频度　；参考：《中国医院药学杂志》2017年11期

【摘要】：目的:分析某院2012年至2015年头孢他啶使用与临床分离的6种主要革兰阴性细菌耐药之间的相关性,为该类抗菌药物的合理应用提供理论依据。方法:从医院信息管理系统(His)中提取该院2012年1月-2015年12月头孢他啶消耗数量(1.0g)及对应年度大肠杆菌等6种临床常见革兰阴性细菌的分离株和其对头孢他啶的耐药数据,采用SPSS 17.0统计软件进行统计分析。结果:大肠杆菌是该院分离最多的一种革兰阴性细菌,其次为克雷伯菌和鲍曼不动杆菌。2013年至今,鲍曼不动杆菌分离数量呈显著增加的趋势。3种细菌对头孢他啶的耐药率呈逐年降低的趋势;与2014年比较,2015年鲍曼不动杆菌对头孢他啶的耐药率降至75.2%。头孢他啶用药频度与大肠杆菌和鲍曼不动杆菌耐药率均呈正相关(P0.05)。结论:随着头孢他啶用量减少,革兰阴性细菌耐药率也随之降低;头孢他啶的用药频度与革兰阴性细菌耐药之间存在一定的相关性;临床工作中应合理使用抗菌药物,降低细菌耐药率。
[Abstract]:Objective: to analyze the relationship between the use of ceftazidime and the drug resistance of 6 major Gram-negative bacteria in a hospital from 2012 to 2015, so as to provide a theoretical basis for the rational application of these antibiotics. Methods: the data of ceftazidime consumption and its resistance to ceftazidime were extracted from Hishe, a hospital information management system, from January 2012 to December 2015, and from 6 common clinical gram-negative bacteria such as Escherichia coli. SPSS 17.0 statistical software was used for statistical analysis. Results: Escherichia coli was the most isolated Gram-negative bacteria, followed by Klebsiella and Acinetobacter baumannii. The resistance rate of acinetobacter baumannii to ceftazidime decreased year by year, and that of Acinetobacter baumannii to ceftazidime decreased to 75.2% in 2015 compared with 2014. The frequency of ceftazidime was positively correlated with the resistance of Escherichia coli and Acinetobacter baumannii. Conclusion: with the decrease of ceftazidime dosage, the rate of drug resistance of Gram-negative bacteria also decreases, there is a certain correlation between the frequency of ceftazidime and the drug resistance of Gram-negative bacteria, and the rational use of antimicrobial agents should be used in clinical work. Reduce the rate of bacterial resistance.
【作者单位】：中国医科大学附属盛京医院药学部;
【基金】：辽宁省自然科学基金项目(编号:2014021090)
【分类号】：R978.1

【相似文献】