miRNA在开发抗流感病毒药物中的研究进展

发布时间：2018-04-24 19:49

本文选题：miRNA + 流感病毒　；参考：《中国药房》2017年04期

【摘要】：目的:为开发新型抗流感病毒药物提供参考。方法:以"流感""抗病毒""micro RNA(mi RNA)""Influenza""Anti-virus"等为关键词,组合查询2001年1月-2016年3月在Pub Med、中国知网、万方、维普等数据库中有关mi RNA在抗流感病毒方面的文献,对内源性mi RNA和外源性植物mi RNA的抗流感病毒作用及其机制进行综述。结果与结论:共检索到相关文献265篇,其中有效文献37篇。抗流感病毒的内源性mi RNA和外源性植物mi RNA对病毒基因的表达具有调控作用。这些mi RNA能靶向流感病毒的基因,如PB1、PB2、NP、M1、NS1等,抑制相应蛋白的表达,影响病毒的复制与转录,从而发挥抗病毒作用。mi RNA在抗流感病毒中发挥着重要作用,但存在很多未知领域,更多的抗病毒mi RNA有待发现。为进一步了解mi RNA在病毒与宿主间所充当的角色以及开发新型抗流感病毒药物,还需深入研究mi RNA的作用机制、调控途径以及生物学功能。
[Abstract]:Objective: to provide a reference for the development of a new type of anti influenza virus drugs. Methods: "influenza" "antiviral" "micro RNA (MI RNA)" "Influenza" "Anti-virus" and so on as the key words, the literature of MI RNA on the anti influenza virus in the database of Pub Med, Chinese know net, Wanfang and VIP in March January 2001 -2016, and the endogenous mi The effect of MI RNA on influenza virus and its mechanism were reviewed. Results and conclusions: 265 articles were retrieved, including 37 effective documents. The endogenous mi RNA and exogenous mi RNA have a regulatory effect on the expression of the virus gene. These mi RNA can target the gene of influenza virus, such as PB1, PB2, NP, M. 1, NS1 and so on, inhibiting the expression of the corresponding protein, affecting the replication and transcription of the virus, and exerting the antiviral effect of.Mi RNA play an important role in the anti influenza virus, but there are many unknown fields, more antiviral mi RNA needs to be found. To further understand the role of Mi RNA in the virus and host and to develop a new anti flow system. It is necessary to further study the mechanism, regulation and biological functions of MI RNA.

【作者单位】：南方医科大学药学院;
【基金】：广州市科技计划项目(No.2014J2200033)
【分类号】：R978.7

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