三七总皂苷联合奥扎格雷钠对血栓素A2合成酶的抑制作用及相互影响

发布时间：2018-04-25 01:13

本文选题：三七总皂苷 + 奥扎格雷钠　；参考：《中华中医药杂志》2015年05期

【摘要】：目的:探讨单独使用三七总皂苷、奥扎格雷钠及两者合用(5∶1,2∶1,1∶1)后对大鼠血清中血栓素A2(TXA2)含量的影响。方法:分别对各组大鼠尾静脉注射三七总皂苷、奥扎格雷钠及两者合用药液后于不同时间点大鼠眼眶取血,加入大鼠TXA2酶联免疫分析试剂盒,采用酶标仪测定大鼠血清中TXA2含量。结果:注射三七总皂苷、奥扎格雷钠组及合用各组大鼠血清中TXA2含量均有所下降(P0.05),且合用组(5∶1)和(2∶1)效果优于合用组(1∶1);另外奥扎格雷钠组在4h时TXA2的含量已恢复到与正常组一样的水平。结论:三七总皂苷对TXA2酶有抑制作用,三七总皂苷与奥扎格雷钠不同的配比亦对TXA2酶有抑制作用,两者联用后可持续平稳的发挥抑制作用,提高疗效,降低用药风险。
[Abstract]:Objective: to investigate the effect of total saponins of Panax notoginseng and sodium ozagrel combined with 5: 1: 2: 1 to 1: 1 on the content of thromboxane A _ 2 (TXA _ 2) in serum of rats. Methods: total saponins of Panax notoginseng, sodium ozagrel and their combined solution were injected into tail vein of rats in each group, and blood was collected from the orbit of rats at different time points, and then added to the TXA2 enzyme linked immunoassay kit of rats. The content of TXA2 in serum of rats was determined by enzyme standard instrument. Results: total saponins of Panax notoginseng were injected, The serum TXA2 content in the ozagrel group and the combined group was lower than that of the control group (P 0.05), and the effect of the combined group was better than that of the combined group (5: 1) and 2: 1). In addition, the content of TXA2 in the ozagrel group had returned to the same level as the normal group at 4 h. Conclusion: panax notoginseng saponins can inhibit TXA2 enzyme, and the different ratio of panax notoginsenoside and ozagrel also has inhibitory effect on TXA2 enzyme.
【作者单位】：北京中医药大学中药学院;
【基金】：国家科技重大专项(No.2014ZX09301306-009,No.2012ZX09103201-017)~~
【分类号】：R965

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