纳米羟基磷灰石的制备及对阿霉素载药性能的考察

发布时间：2018-04-25 17:47

  本文选题：纳米羟基磷灰石 + 化学共沉淀　； 参考：《沈阳药科大学学报》2017年01期

【摘要】：目的合成药物载体纳米羟基磷灰石(nano-hydroxyapatite,nHAP),考察其对于模型药物阿霉素的载药性能。方法采用化学共沉淀法,以Ca(NO3)2·4H2O和(NH4)2HPO4分别为钙、磷源,用氨水调控溶液p H值合成nHAP,考察温度、反应时间和陈化时间对于nHAP合成的影响。采用X射线衍射仪、扫描电镜、红外光谱仪、动态光散射粒度测定仪对于产品的晶相、晶貌、化学组成和粒径进行表征。采用溶液吸附法考察nHAP用量、溶液质量浓度和p H值对于nHAP负载阿霉素的影响。结果当反应温度60℃、反应时间2 h、陈化时间16 h时,所制备的nHAP为长(138±35)nm,宽(39±8)nm棒状纳米粒,晶体形貌规则,结晶良好。负载阿霉素的研究表明,所合成的nHAP载药性能良好,载药量达到42.43 mg·g~(-1)。结论 nHAP对于阿霉素具有良好的承载能力,可作为阿霉素的优良载体。
[Abstract]:Aim to synthesize hydroxyapatite nano-hydroxyapatite nano-hydroxyapatite (HAPP) as drug carrier and to investigate its drug loading properties for adriamycin (adriamycin). Methods using Ca(NO3)2 4H2O and NH _ 4H _ 4HPO _ 4 as calcium and phosphorus sources, NH _ 4 and NH _ 4H _ 2HPO _ 4 were used to control pH value of solution to synthesize nHAPs by chemical coprecipitation method. The effects of temperature, reaction time and aging time on the synthesis of nHAP were investigated. The crystal phase, crystal appearance, chemical composition and particle size of the product were characterized by X-ray diffractometer, scanning electron microscope, infrared spectrometer and dynamic light scattering particle size analyzer. The effects of nHAP dosage, solution concentration and pH value on nHAP loaded adriamycin were investigated by solution adsorption method. Results when the reaction temperature was 60 鈩，

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