合成化合物动物体内抗肿瘤实验方法研究进展

发布时间：2018-04-30 01:09

本文选题：合成化合物 + 抗肿瘤药物　；参考：《化学通报》2015年08期

【摘要】：进行了动物体内抗肿瘤活性研究的多为天然药物,但其来源有限;虽然用于抗肿瘤研究的合成化合物种类较多,但对于其在动物体内抗肿瘤研究又相对偏少,所以,合成化合物抗肿瘤体内研究已经成为研究热点之一。本文对合成化合物抗肿瘤作用机制、体内肿瘤模型建立方法和体内抑瘤实验研究等方面的研究进展进行了评述,并通过大量实验数据对合成化合物毒性评价方法、抑瘤基本观察指标测定、氧化损伤相关酶活力的测定方法、组织病理学评价方法等体内抑瘤实验的评价标准和方法进行了详细总结,提出了合成化合物在体内动物抗肿瘤实验研究方法中亟待解决的问题,为新型抗肿瘤合成化合物体内药学活性研究提供有益的参考。
[Abstract]:Most of the studies on antitumor activities in animals are natural drugs, but their sources are limited. Although there are many kinds of synthetic compounds used in antitumor studies, there are relatively few studies on their antitumor activities in animals, so, Anti-tumor studies of synthetic compounds have become one of the hotspots in vivo. In this paper, the mechanism of antitumor action of synthetic compounds, the methods of establishing tumor models in vivo and the experimental study of tumor inhibition in vivo are reviewed, and the toxicity evaluation methods of synthetic compounds are evaluated by a large amount of experimental data. The evaluation criteria and methods of tumor inhibition in vivo were summarized in detail, such as the measurement of basic tumor inhibition indexes, the determination of enzyme activity related to oxidative injury, and the evaluation methods of histopathology. The problems to be solved in the experimental research on the antitumor activity of synthetic compounds in vivo are put forward, which provides a useful reference for the study of the pharmacological activities of new antitumor synthetic compounds in vivo.
【作者单位】：哈尔滨工业大学生物化工系;哈尔滨医科大学附属第一医院;哈尔滨师范大学功能材料的设计合成与绿色催化黑龙江省高校重点实验室;
【基金】：国家自然科学基金项目(21271056,21371042) 黑龙江省自然科学基金项目(B2015~003,H2015065) 黑龙江省博士后基金项目(LBH-Z15292) 黑龙江省卫生厅科研课题(2010-030)资助
【分类号】：R96

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