经结构修饰的Pluronic P123在药物递送中的应用

发布时间：2018-05-01 14:36

本文选题：Pluronic + P　；参考：《中国医药工业杂志》2017年06期

【摘要】：Pluronic P123(P123)是泊洛沙姆类聚合物中的一种,具有增加水难溶性药物的溶解度、延长体内循环时间、增加药物的细胞内摄取、抑制肿瘤的迁移、逆转多药耐药和增强药物的疗效等作用,在递送药物方面具有众多优势。通过对P123末端羟基的结构修饰,P123能以酯键、酰胺键和糖苷键等化学键与其他物质结合而生成新的材料,用以制备Pluronic P123-药物结合物胶束体系、配体介导的主动靶向转运系统及其他药物递送系统,增加药物或基因向靶组织的递送。本文综述了结构修饰后的P123在药物递送方面的应用。
[Abstract]:Pluronic P123P123) is one of Poloxamer polymers, which can increase the solubility of water-insoluble drugs, prolong the circulation time in vivo, increase the intracellular uptake of drugs, inhibit tumor migration, reverse multidrug resistance and enhance the efficacy of drugs. There are many advantages in delivering drugs. By modifying the structure of P123 terminal hydroxyl group, P123 can combine ester bond, amide bond and glycoside bond with other materials to form new materials, which can be used to prepare Pluronic P123-drug conjugate micelle system. Ligand-mediated active targeting transport systems and other drug delivery systems increase drug or gene delivery to target tissues. The application of structurally modified P123 in drug delivery is reviewed in this paper.
【作者单位】：河北北方学院药学系;
【基金】：河北省中医药管理局(2017212) 河北北方学院基金项目(GZ1405)
【分类号】：R943

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