碱性蒙脱石抗酸剂性能测定及评价

发布时间：2018-05-01 22:49

本文选题：碱性蒙脱石 + 抗酸剂　；参考：《中国药学杂志》2015年02期

【摘要】：目的对碱性蒙脱石抗酸剂进行性能测定及评价。方法测定抗酸剂的活性成分含量、溶解度及粒度等参数,并进行BET、X-射线衍射法(XRD)和扫描电镜(SEM)表征分析,通过急性毒性实验、体外抗酸实验以及胃黏膜保护实验对抗酸剂进行评价。结果活性成分Ca(OH)2的含量和溶解度分别为37%和84 mg·L-1,活性成分Ca(OH)2负载比较牢固,碱强度大大下降。粒度和比表面积分别为8.3μm和37.5 m2·g-1,有利于吸附胃酸和形成胃黏膜保护。X-射线衍射法表征结果显示,抗酸剂保留了蒙脱石的结构,扫描电镜图谱显示,抗酸剂的表面比较光滑,利于黏膜保护。急性毒性实验、体外抗酸实验和胃黏膜保护实验结果表明,抗酸剂安全无毒,并表现出优良的抗酸和胃黏膜保护性能。结论碱性蒙脱石抗酸剂是一种优良的抗酸剂及胃黏膜保护剂。
[Abstract]:Objective to determine and evaluate the properties of alkaline montmorillonite antiacid. Methods the active component content, solubility and particle size of the antacid were determined. The results were characterized by BETX ray diffraction and scanning electron microscopy (SEM), and the acute toxicity test was carried out. In vitro acid-fast test and gastric mucosal protection test were used to evaluate the anti-acid agent. Results the content and solubility of active component Ca(OH)2 were 37% and 84 mg / L, respectively. The loading of active component Ca(OH)2 was relatively firm, and the alkali strength decreased greatly. The particle size and specific surface area were 8.3 渭 m and 37.5 m ~ 2 g ~ (-1), respectively, which were beneficial to the absorption of gastric acid and the formation of gastric mucosal protection. The results of X-ray diffraction showed that the antiacid retained the structure of montmorillonite, and the surface of the antiacid was smooth. It is beneficial to mucosal protection. The results of acute toxicity test, in vitro acid-resistance test and gastric mucosal protection test showed that the anti-acid agent was safe and non-toxic, and showed excellent anti-acid and gastric mucosal protection properties. Conclusion Alkaline montmorillonite antiacid is an excellent antiacid and gastric mucosal protective agent.
【作者单位】：广西大学化学化工学院广西石化资源加工及过程强化技术重点实验室;
【基金】：国家自然科学基金资助项目(21166004)
【分类号】：R96

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