盐酸环丙沙星胃漂浮缓释片的设计、制备与体外评价

发布时间：2018-05-02 17:43

本文选题：盐酸环丙沙星 + 亲水骨架材料　；参考：《中国药学杂志》2015年24期

【摘要】：目的考察聚合物,包括亲水凝胶骨架材料及膨胀剂,对盐酸环丙沙星胃漂浮缓释片漂浮性能和释放行为的影响。方法分别以羟丙甲纤维素(HPMC),羟丙纤维素(HPC)和羟乙基纤维素(HEC)为亲水凝胶骨架材料,以交联聚维酮(PVPP XL,PVPP XL-10)和交联羧甲基纤维素钠(CCS)为膨胀剂,制备盐酸环丙沙星胃漂浮缓释片,以起漂时间,漂浮持续时间和漂浮力为指标评价漂浮性能,以盐酸环丙沙星释放度为指标评价缓释性能。结果羟丙甲纤维素K250与交联聚维酮交联聚维酮XL合用可以获得起漂时间较短,漂浮持续时间较长且药物体外释放较理想的盐酸环丙沙星胃漂浮缓释片。结论聚合物的种类和用量对胃漂浮片的漂浮性能和药物释放特性具有显著影响,羟丙甲纤维素K250和交联聚维酮XL是制备盐酸环丙沙星胃漂浮缓释片的较合适聚合物。
[Abstract]:Objective to investigate the effect of polymer, including hydrophilic gel skeleton material and dilatant, on the floatability and release behavior of ciprofloxacin hydrochloride gastric floating sustained-release tablets. Methods ciprofloxacin hydrochloride sustained-release tablets were prepared by hydrophilic gel framework materials of HPMCX, HPC and HECs, and crosslinked polyvinylidene (PVPP) PVPP XL-10) and cross-linked sodium carboxymethyl cellulose (CCS), respectively. Floatation time, floating duration and floating force were used as indicators to evaluate the floatability, and ciprofloxacin hydrochloride release rate was used as the index to evaluate the sustained release performance of ciprofloxacin hydrochloride (ciprofloxacin hydrochloride). Results Hydroxypropyl methyl cellulose K250 combined with cross-linked polyvidone XL could obtain ciprofloxacin hydrochloride floating sustained-release tablets with shorter bleaching time longer floating time and better drug release in vitro. Conclusion the type and dosage of polymer have significant effects on the floating properties and drug release properties of gastric floating tablets. HPMC K250 and cross-linked polyvinylethone XL are the more suitable polymers for the preparation of ciprofloxacin hydrochloride gastric floating sustained-release tablets.
【作者单位】：亚什兰(中国)投资有限公司;
【分类号】：R944

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