我院重症感染新生儿应用万古霉素血药浓度监测结果分析

发布时间：2018-05-05 22:15

本文选题：万古霉素 + 重症感染　；参考：《中国药房》2015年15期

【摘要】：目的:为促进重症感染新生儿合理应用万古霉素提供参考。方法:回顾性分析我院2012年6月-2014年6月间重症感染新生儿的万古霉素血药浓度监测结果及其相关信息。结果:30例重症感染新生儿应用万古霉素治疗总有效率为63.33%。其中,7例稳态谷浓度小于10 mg/L(占23.33%),有效率为16.67%;22例在10~20 mg/L(占73.33%),有效率为77.27%;1例大于20 mg/L(占3.33%),有效率为100%。有2例采用qd给药,疗程最短的仅2 d。病原学检查送检率为96.67%,其中阳性率为89.65%。治疗期间未发现患儿有明显不良反应及肝、肾功能损害情况。结论:我院重症感染新生儿应用万古霉素治疗总有效率偏低,可能与万古霉素的稳态谷浓度偏低有关。部分临床应用尚不够规范,存在疗程不足、给药间隔不当等不合理用药情况。严格按标准使用及加强血药浓度监测对指导万古霉素临床合理应用具有重要意义。
[Abstract]:Objective: to provide reference for the rational application of vancomycin in neonates with severe infection. Methods: the monitoring results of vancomycin concentration in neonates with severe infection from June 2012 to June 2014 were analyzed retrospectively. Results the total effective rate of vancomycin in 30 newborns with severe infection was 63.33. Among them, the steady-state valley concentration in 7 cases was less than 10 mg / L (23.33%), the effective rate was 16.67% and 22 cases were 10 ~ 20 mg / L (73.33%), and the effective rate was 77.27% > 20 mg / L (3.33%, the effective rate was 100). Two cases were given QD, the shortest course of treatment was only 2 days. The rate of pathogenic examination was 96.67 and the positive rate was 89.65. During the treatment, no obvious adverse reactions and liver and renal function damage were found in the children. Conclusion: the total effective rate of vancomycin in neonates with severe infection in our hospital is low, which may be related to the low steady-state valley concentration of vancomycin. Part of the clinical application is not standardized, there are insufficient course of treatment, inappropriate interval of administration of irrational drug use. Strictly according to the standard and strengthen the monitoring of blood concentration of vancomycin has important significance in guiding the rational clinical application of vancomycin.
【作者单位】：深圳市龙岗区妇幼保健院临床药学室;
【分类号】：R969

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