载汉防己甲素磁性聚乳酸-羟基乙酸共聚物纳米粒及磁感应加热诱导药物释放的研究

发布时间：2018-05-06 02:23

  本文选题：汉防己甲素 + 聚乳酸-羟基乙酸共聚物　； 参考：《中国药学杂志》2015年21期

【摘要】：目的制备载汉防己甲素的磁性聚乳酸-羟基乙酸共聚物(PLGA)纳米粒,通过磁感应诱导加热纳米粒,研究加热前后载药磁性纳米粒粒径,形态学及药物释放的变化。方法采用乳化分散溶剂挥发法制备载汉防己甲素聚乳酸-羟基乙酸共聚物磁性纳米粒;利用激光粒径仪(DLS)、扫描电镜(SEM)、透射电镜(TEM)、振动样品磁强计(VSM)对纳米粒的理化性质及磁性能进行考察;采用RP-HPLC及ICP-MS测定药物及Fe3O4载药量、包封率。EASYHEAT磁感应加热系统对载药纳米粒进行加热,考察加热前后纳米粒粒径,形态及药物释放量的变化。结果载汉防己甲素聚乳酸-羟基乙酸共聚物磁性纳米粒呈大小均一,表面光滑圆球形,磁性颗粒均匀分散在聚乳酸-羟基乙酸共聚物纳米粒内部;振动样品磁强计结果显示,载汉防己甲素磁性聚乳酸-羟基乙酸共聚物纳米粒具有良好的超顺磁性;汉防己甲素及Fe3O4均具有良好的包封率和载药量。运用磁感应加热至45℃后,磁性纳米粒粒径变大,形态发生聚集破裂,聚乳酸-羟基乙酸共聚物纳米粒内Fe3O4磁性颗粒发生重排,药物释放量明显增加。结论具超顺磁性载汉防己甲素聚乳酸-羟基乙酸共聚物纳米粒,在磁感应加热作用下,能有效控制药物的释放。
[Abstract]:Objective to prepare magnetic polylactic acid-glycolic acid (PLGA) nanoparticles loaded with Tetrandrine (Tetrandrine), and to study the changes of particle size, morphology and drug release before and after heating. Methods the magnetic nanoparticles of Tetrandrine loaded polylactic acid-glycolic acid copolymers were prepared by emulsifying and dispersing solvent volatilization method. The physicochemical properties and magnetic properties of the nanoparticles were investigated by laser particle size analyzer, scanning electron microscope (SEM), transmission electron microscope (TEM) and vibratory sample magnetometer (VSM), and the amount of drugs and Fe3O4 loaded in the nanoparticles were determined by RP-HPLC and ICP-MS. The encapsulation efficiency. EASYHEAT magnetic induction heating system was used to heat the drug loaded nanoparticles. The changes of particle size, morphology and drug release before and after heating were investigated. Results the magnetic nanoparticles of Tetrandrine (Tetrandrine) polylactic acid-glycolic acid copolymers were uniform in size, and the surface was smooth and spherical, the magnetic particles were evenly dispersed in the interior of polylactic acid-glycolic acid copolymer nanoparticles, and the results of vibrating sample magnetometer showed that, Tetrandrine loaded magnetic poly (lactic acid-glycolic acid) copolymer nanoparticles have good superparamagnetic properties, Tetrandrine and Fe3O4 have good encapsulation efficiency and drug loading. When heated to 45 鈩，

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