国产头孢雷特的体外抗菌活性研究

发布时间：2018-05-06 16:53

本文选题：国产头孢雷特 + 体外　；参考：《中国临床药理学杂志》2015年22期

【摘要】：目的评价国产头孢雷特体外抗菌活性。方法用琼脂二倍稀释法,测定国产头孢雷特对617株临床分离致病菌的最低抑菌浓度(MIC)。结果国产头孢雷特对临床分离甲氧西林敏感性金黄色葡萄球菌、β溶血性链球菌、超广谱β内酰胺酶阴性(ESBLs-)大肠埃希菌、ESBL-肺炎克雷伯菌、变形杆菌属、伤寒沙门菌、流感嗜血杆菌、卡他莫拉菌有较强抗菌作用,MIC90值在0.25~8 mg·L-1。结论国产头孢雷特体外抗菌活性,抗菌谱与头孢呋辛、头孢孟多酯、头孢替安相似,对大多数革兰氏阴性菌的抗菌效力较强;其耐药率与对照相当。
[Abstract]:Objective to evaluate the antibacterial activity of domestic cefrett in vitro. Methods the minimum inhibitory concentration of ceforette against 617 strains of clinical pathogenic bacteria was determined by Agar dilution method. Results ceforette was resistant to clinical isolation of methicillin-sensitive Staphylococcus aureus, 尾 hemolytic streptococcus, extended-spectrum 尾 -lactamase negative Escherichia coli, Klebsiella pneumoniae, Proteus, Salmonella typhimurium. The MIC90 value of Haemophilus influenzae and Mora carinii was 0.25 mg / L ~ (-1) and 0.25 mg / L ~ (-1) respectively. Conclusion the antibacterial activity of domestic ceflatte in vitro is similar to that of cefuroxime, cefotriol and ceftidine, and the antimicrobial activity against most gram-negative bacteria is stronger, and the drug resistance rate is similar to that of the control.
【作者单位】：北京大学第一医院临床药理研究所;
【分类号】：R96

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