药物经济学评价Markov模型实例解析

发布时间：2018-05-10 14:19

  本文选题：胃癌 + Markov模型　； 参考：《中国医院药学杂志》2015年18期

【摘要】：目的:本文旨在对已建立的Markov模型进行解析,为中国胃癌治疗方案的药物经济学研究奠定基础。方法:深入分析Markov模型建立的理由和方法。结果:胃癌治疗后的自然转归符合Markov基本原理,可划分为三种互不相容的生存状态,合理假设可简化Markov模型,转移概率是Markov模型是否正确的关键。结论:对中国胃癌患者两种治疗方案进行药物经济学评价,可采用划分3种互不相容健康状态,使用TreeAge软件创建Markov模型,利用公开发表的大型Ⅲ期临床试验结果,结合WHO生命表数据确定转移概率,以此创建切实可行的Markov模型。
[Abstract]:Objective: to analyze the established Markov model in order to lay a foundation for the pharmacoeconomic study of gastric cancer treatment in China. Methods: the reasons and methods for establishing Markov model were analyzed. Results: the natural outcome of gastric cancer after treatment was consistent with the basic principle of Markov and could be divided into three incompatible living states. The reasonable assumption could simplify the Markov model, and the transfer probability was the key to the correctness of Markov model. Conclusion: according to the pharmacoeconomic evaluation of two treatment schemes for gastric cancer patients in China, we can use TreeAge software to create Markov model and make use of the published results of large stage 鈪，

本文编号：1869646