我院双硫仑样反应82例分析

发布时间：2018-05-14 00:24

本文选题：双硫仑样反应 + 头孢菌素类　；参考：《中国药房》2015年29期

【摘要】：目的:为临床安全、合理用药提供参考。方法:收集广州中医药大学第一附属医院2012年7月1日-2014年6月30日期间所收治及发生的双硫仑样反应的病例资料并进行回顾分析,总结其发生的流行病学特点、发生原因、临床表现特征及救治措施。结果:双硫仑样反应的男性发生率较高(占86.59%),主要发生于21~50岁中青年(占78.05%);其发生原因与使用头孢菌素类抗菌药物(如头孢哌酮、头孢哌酮/舒巴坦)、硝基咪唑类(如甲硝唑、替硝唑等)及饮用或接触含乙醇的饮料、药物或食品等有关;其涉及皮肤及其附件、循环系统、消化系统、神经系统和呼吸系统等,主要表现为皮肤潮红、胸闷、气短、心悸、恶心、呕吐、头晕、头痛等,偶见意识不清、嗜睡、口干等;对严重的双硫仑样反应的救治采用基础治疗结合对症处理,1~3 h内症状缓解,未见死亡病例。结论:应用含甲硫四氮唑基团的药物如头孢菌素类抗菌药物、硝基咪唑类等前后应避免饮酒或服用含有乙醇的药品或食物,以防双硫仑样反应的发生。
[Abstract]:Objective: to provide reference for clinical safety and rational use of drugs. Methods: the data of cases of disulfiromlike reaction admitted and occurred in the first affiliated Hospital of Guangzhou University of traditional Chinese Medicine from July 1, 2012 to June 30, 2014 were collected and analyzed retrospectively, and the epidemiological characteristics and causes were summarized. Clinical features and treatment measures. Results: the incidence of disulfiromlike reaction was higher in men (86.59%), mainly in the middle and young people (78.05%) aged 21 to 50 years, the cause of which was associated with the use of cephalosporins (such as cefoperazone, cefoperazone / sulbactam), nitroimidazole (such as metronidazole). Of or relating to drink, medicine, or food containing ethanol; involving the skin and its accessories, circulatory system, digestive system, nervous system, respiratory system, etc., characterized by redness of the skin, chest tightness, shortness of breath, palpitations, etc. Nausea, vomiting, dizziness, headache, occasional confusion, drowsiness, dry mouth, etc. Conclusion: drugs containing methyl thiotetrazole such as cephalosporins and nitroimidazoles should be avoided from drinking or taking ethanol-containing drugs or foods in order to prevent the occurrence of dithiolon-like reactions.
【作者单位】：华南肿瘤学国家重点实验室/中山大学附属肿瘤医院药学部;广州中医药大学第一附属医院药学部;
【分类号】：R595.3

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