缩短静脉用药集中调配时难溶性药物溶解时间的方法

发布时间：2018-05-20 05:35

本文选题：静脉用药集中调配 + 难溶性药物　；参考：《医学研究生学报》2015年04期

【摘要】：目的根据难溶性药物的不同特点,分析影响其溶解速度的因素,采取适当的配置方法,加快难溶性药物的溶解速度,减少配置所需时间,提高配置效率。方法将门冬氨酸鸟氨酸、美洛西林钠舒巴坦钠、替考拉宁、奥美拉唑钠注射液、亚胺培南西司他丁钠等5种难溶性药物的常规配药方法作为对照组,以增加溶媒量、配置前敲松药瓶内药粉、减少泡沫产生、使用专用溶媒及提高溶解温度等改进后的方法分别作为5种药物配置的实验组进行观察和对比实验,药物配置完成至完全溶解为澄清透明液体计时。结果门冬氨酸鸟氨酸、美洛西林钠舒巴坦钠、替考拉宁、奥美拉唑钠注射液、亚胺培南西司他丁钠等药物实验组完全溶解为澄清透明液体平均需时分别为(42±5)s、(3±1)min、(5±1)min、(5±3)s、(2±1)min,显著少于对照组平均需时(246±35)s、(30±3)min、(10±3)min、(10±5)s、(10±1)min。5种药物经过改进前后不同配置方法比较,完全溶解时间差异有统计学意义(P0.05)。结论采取适当增加溶媒量、加药前敲松药粉、减少加药过程中泡沫产生、专用溶媒的使用及提高溶解温度等溶解方法,可有效缩短难溶性药物的溶解时间,提高静脉用药配置效率。
[Abstract]:Objective according to the different characteristics of insoluble drugs, the factors affecting the dissolution rate of insoluble drugs were analyzed, and the appropriate allocation methods were adopted to accelerate the dissolution rate of insoluble drugs, reduce the time required for allocation and improve the allocation efficiency. Methods five insoluble drugs, such as ornithine aspartate, meloxicillin sodium, sulbactam sodium, teicoplanin, omeprazole sodium injection and imipenem aspartate sodium, were used as control group. The improved methods, such as knocking out the powder in the bottle before disposition, reducing foam production, using special solvent and raising the dissolution temperature, were observed and compared with each other in the experimental group of 5 kinds of drugs, respectively. The drug configuration is completed until completely dissolved to clarify the transparent liquid timing. Results Ornithine aspartate, meloxicillin sodium, sulbactam sodium, teicoplanin, omeprazole sodium injection, The average time required for the complete dissolution of imipenem to clarify transparent liquid in the experimental group was 42 卤5 minutes, 3 卤1 minute, 5 卤1 minute, 5 卤3 minutes, 2 卤1 minute, significantly lower than that in the control group, which was 30 卤3 minutes, 10 卤3 minutes, 10 卤5 minutes and 10 卤5 1)min.5, respectively, and compared with the different methods before and after the improvement. The difference of complete dissolution time was statistically significant (P 0.05). Conclusion the dissolution time of insoluble drugs can be effectively shortened by increasing the amount of solvent properly, knocking out the powder before adding, reducing the foam production in the process of adding drugs, using the special solvent and raising the dissolution temperature, etc. To improve the efficiency of intravenous drug allocation.
【作者单位】：南京医科大学附属南京医院(南京市第一医院)静脉用药调配中心;
【基金】：南京市医学科技发展项目(YKK10100)
【分类号】：R95

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