内分泌病区因药物不良反应入院的主动监测研究

发布时间：2018-05-22 10:06

本文选题：因不良反应住院 + 内分泌　；参考：《中国药学杂志》2015年12期

【摘要】：目的通过主动监测的方式获取我院内分泌病区因药物不良反应(ADR)入院的发生率及主要特征,为临床安全用药提供参考。方法临床药师通过床旁问诊方式采集内分泌病区2011年1月至2013年12月因药物不良反应入院患者的详细资料,并对药物不良反应类型、临床表现、怀疑药物、过敏史、住院时间、住院费用以及转归情况进行分析。结果 6 914例入院患者中共有40例因药物不良反应入院,占0.58%,男性13例,女性27例,平均年龄(54.82±15.85)岁,平均住院费用(10622.86±6 719.48)元,住院天数(12.85±7.57)d,其中A型药物不良反应有34例(85.0%),B型药物不良反应有6例(15.0%)。40例药物不良反应共11种药物不良反应表现类型,涉及怀疑药物27种,主要的药物不良反应表现有低血糖、肾小管损害继发低磷软骨,类固醇糖尿病,粒细胞缺乏(减少)、胰岛素过敏、低血钾,肝酶升高,胰岛素自身免疫综合症,电解质紊乱,甲亢以及甲减,涉及的怀疑药物主要有胰岛素、口服降糖药物,降糖中成药(保健品)、甲巯咪唑、阿德福韦酯、肾上腺皮质激素等。结论内分泌病区因药物不良反应住院的比例0.58%,但引起药物不良反应的多为内分泌的常用药物,药物不良反应表现如低血糖、低血钾、电解质紊乱等与内分泌系统疾病临床表现相似,常常会影响诊断,延误治疗,因此在诊疗过程中,应重视药物的药物不良反应因素。
[Abstract]:Objective to obtain the incidence and main characteristics of ADR in endocrine ward of our hospital by active monitoring, so as to provide reference for safe drug use in clinic. Methods from January 2011 to December 2013, the clinical pharmacists collected the detailed data of patients admitted to the endocrine ward for adverse drug reactions from January 2011 to December 2013, and analyzed the types of adverse drug reactions, clinical manifestations, suspected drugs, history of allergies, and length of stay. Hospital expenses and outcomes were analyzed. Results A total of 40 patients (0.58%) were admitted to hospital because of adverse drug reactions. There were 13 males and 27 females, with an average age of 54.82 卤15.85 years and an average hospitalization cost of 10622.86 卤6719.48 yuan. The number of days in hospital was 12.85 卤7.57 days, of which 34 cases of type A drug adverse reactions (ADRs) were 85.0% (6 / 40). There were 11 types of adverse drug reactions (ADRs) involving 27 suspected drugs. The main adverse drug reactions were hypoglycemia. Renal tubular damage secondary to hypophosphorous cartilage, steroid diabetes, granulocyte deficiency, insulin allergy, hypokalemia, liver enzyme elevation, insulin autoimmune syndrome, electrolyte disorders, hyperthyroidism, and hypothyroidism, The main suspected drugs involved include insulin, oral hypoglycemic drugs, hypoglycemic traditional Chinese medicine (health care products, methimazole, adefovir, adrenal corticosteroids, etc. Conclusion the proportion of patients hospitalized with adverse drug reactions in endocrine areas is 0.58, but the adverse drug reactions are mostly common endocrine drugs, such as hypoglycemia, hypokalemia, hypoglycemia and hypokalemia. Electrolyte disorders are similar to the clinical manifestations of endocrine system diseases, which often affect diagnosis and delay treatment. Therefore, in the course of diagnosis and treatment, attention should be paid to the adverse drug reaction factors.
【作者单位】：解放军总医院药品保障中心;解放军总医院内分泌科;
【基金】：解放军总医院科技创新苗圃基金资助项目(13KMM46)
【分类号】：R969.3

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