化学生物学在青蒿素靶标与作用机制中的研究进展

发布时间：2018-05-22 10:26

本文选题：青蒿素 + 过氧桥　；参考：《科学通报》2017年18期

【摘要】：青蒿素是中国科学家屠呦呦及其研究团队从黄花蒿中分离得到的抗疟药物,在全世界治疗疟疾的过程中发挥了重要作用.随着屠呦呦2015年获得诺贝尔生理学或医学奖,青蒿素的研究再次成为热点.随着对青蒿素研究的深入,人们发现,除具有抗疟活性外,青蒿素还具有其他药理活性,包括抗肿瘤、抗哮喘等.虽然全世界的学者们发表了大量与青蒿素相关的研究文章,但是其具体的抗疟活性以及抗肿瘤活性作用机制并不明确.青蒿素的作用机制非常复杂,尤其是其激活过程.最近,随着化学生物学平台在青蒿素作用机制研究中的应用,青蒿素研究有了新的突破,本文将着重介绍近年来化学生物学在青蒿素作用机制研究中的最新进展.
[Abstract]:Artemisinin, an antimalarial drug isolated from Artemisia annua by Chinese scientist Tu Youyou and his team, plays an important role in the treatment of malaria worldwide. With Tu winning the Nobel Prize in Physiology or Medicine in 2015, artemisinin research has once again become a hot topic. With the further study of artemisinin, it has been found that artemisinin also has other pharmacological activities, including anti-tumor, anti-asthma, in addition to antimalarial activity. Although scholars all over the world have published a large number of artemisinin-related research papers, its specific antimalarial activity and the mechanism of its anti-tumor activity are not clear. The mechanism of artemisinin action is very complicated, especially its activation process. Recently, with the application of chemical biological platform in the study of the mechanism of artemisinin action, there has been a new breakthrough in the research of artemisinin. This article will focus on the recent advances in the study of the mechanism of artemisinin action by chemical biology.
【作者单位】： Department
【基金】：国家自然科学基金(81641002)资助
【分类号】：R96

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