天然乳化剂阿拉伯胶对绿原酸自微乳体内外性能的影响

发布时间：2018-05-23 19:43

本文选题：阿拉伯胶 + 绿原酸　；参考：《中国药房》2017年25期

【摘要】：目的:研究天然乳化剂阿拉伯胶对绿原酸自微乳体内外性能的影响。方法:以阿拉伯胶逐步取代含非离子型乳化剂的绿原酸自微乳(简称"传统绿原酸自微乳")中的聚山梨酯80制成含阿拉伯胶的绿原酸自微乳(简称"新型绿原酸自微乳"),评价两种自微乳的外观、乳滴形态、粒径、电导率、p H值、稳定性、体外释放度和肠吸收动力学指标。结果:新型绿原酸自微乳采用阿拉伯胶取代了聚山梨酯80处方量的50%。传统和新型绿原酸自微乳的微乳液外观澄明,乳滴为近似球形,粒径分别为(24.53±3.03)、(35.51±5.91)nm,电导率分别为(195.6±0.3)、(189.5±0.4)μs/cm,p H分别为3.87±0.02、4.08±0.03(n=3)。与传统绿原酸自微乳比较,新型绿原酸自微乳在十二指肠、空肠、回肠中的吸收速率常数、有效渗透系数和吸收量均略有增加(P0.05),在结肠中的上述指标均明显降低(P0.05)。结论:新型绿原酸自微乳可保持传统绿原酸自微乳的性能,并能增加绿原酸在小肠的吸收。
[Abstract]:Objective: to study the effect of natural emulsifier Arabic gum on the properties of Lv Yuan acid self-emulsion in vitro and in vivo. Methods: the Lv Yuan acid self-microemulsion containing Arabic gum (abbreviated as "new Lv Yuan acid") was prepared by replacing the polysorbate 80 in the Lv Yuan acid self-microemulsion containing non-ionic emulsifier ("traditional Lv Yuan acid self-microemulsion") with Arabic gum step by step. The appearance of two self-microemulsions was evaluated. Droplet morphology, particle size, conductivity and pH value, stability, in vitro release and intestinal absorption kinetics. Results: the new self-microemulsion of Lv Yuan acid replaced 50% of the prescription of polysorbate 80 by Arabic gum. The microemulsion of traditional and new Lv Yuan acid self-microemulsions has a clear appearance, the droplets are nearly spherical, the particle size is 24.53 卤3.03nm, the electrical conductivity is 195.6 卤0.3nmand the conductivity is 189.5 卤0.4) 渭 s / cm ~ (-1) H = 3.87 卤0.024.08 卤0.03n ~ (-1) nm, respectively. Compared with the traditional Lv Yuan self-microemulsion, the absorption rate constant, effective osmotic coefficient and absorption amount of the new Lv Yuan self-microemulsion in duodenum, jejunum and ileum increased slightly, and the above indexes in colon decreased significantly. Conclusion: the new Lv Yuan acid self-microemulsion can maintain the properties of the traditional Lv Yuan acid self-microemulsion and increase the absorption of Lv Yuan acid in the small intestine.
【作者单位】：遵义医学院药学院;
【基金】：贵州省科学技术基金项目(No.黔科合J字LKZ[2013]26号)
【分类号】：R943

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