羧甲基-β-环糊精用于氢化安息香和联萘酚磷酸酯的毛细管电泳拆分

发布时间：2018-05-26 21:48

  本文选题：高效毛细管电泳 + 手性拆分　； 参考：《南开大学学报(自然科学版)》2017年01期

【摘要】：以羧甲基-β-CD(CM-β-CD)为手性添加剂,用毛细管区带电泳法对氢化安息香和联萘酚磷酸酯的消旋体进行了拆分研究.实验考察了CM-β-CD的浓度、背景电解质的p H值、分离电压对对映体分离的影响.结果表明,以100 mmol/L Tris-磷酸为缓冲液,CM-β-CD的浓度在5-30 mg/m L,p H值7.5-10.0之间,电压在10-30 k V之间,温度在25℃时,氢化安息香和联萘酚磷酸酯均能获得基线分离.该方法简便、快速、分离范围宽,可用于氢化安息香和联萘酚磷酸酯的手性分离.
[Abstract]:The resolution of racemates of hydrogenated benzoin and binaphthol phosphate was studied by capillary zone electrophoresis with carboxymethyl- 尾 -CD-CD-CM- 尾 -CD as chiral additive. The effects of concentration of CM- 尾 -CD, pH value of background electrolyte and separation voltage on enantiomeric separation were investigated. The results show that when the concentration of CM- 尾 -CD in 100 mmol/L Tris-phosphoric acid buffer is between 7.5 and 10.0 for 5-30 mg/m, the voltage is between 10-30 kV and the temperature is 25 鈩，

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