偶合常数分析在柔性天然分子相对构型鉴定中的应用

发布时间：2018-05-29 12:28

本文选题：偶合常数 + 柔性分子　；参考：《国际药学研究杂志》2015年06期

【摘要】：天然产物中的柔性结构片段可自由旋转,其相对构型的确定仍然具有相当的挑战性。基于偶合常数的构型分析方法(JBCA)可有效地解决该类问题。该法主要应用于邻/间二次甲基柔性结构片段,结合氢-氢和碳-氢偶合常数(3JH,H,2,3JH,C)以及核欧沃豪斯效应(NOE)测试对柔性结构片段进行构象分析,进而确定其相对构型。本文简要综述了该法近年来在柔性天然分子结构鉴定中的研究进展,希望为天然产物立体化学研究提供一定参考。
[Abstract]:The flexible structure fragments in natural products can be rotated freely, and the determination of their relative configurations is still quite challenging. JBCA, a configuration analysis method based on coupling constants, can effectively solve this kind of problems. The method is mainly applied to the analysis of the flexible structure fragments of o / m dimethyl, combined with the coupling constants of hydrogen, hydrogen and carbon to hydrogen, and the NOEs effect of the nuclear Ovalhaus effect, and then the relative configuration of the flexible structure fragments is determined by means of the combination of the coupling constants of hydrogen and hydrogen, as well as the NOEs effect of the nuclear Ovalhaus effect. In this paper, the research progress of this method in the identification of flexible natural molecular structure in recent years is briefly reviewed. It is hoped that this paper will provide some references for the study of stereochemistry of natural products.
【作者单位】：第二军医大学药学院海洋药物研究中心/海洋生物医药研究所;
【基金】：国家自然科学基金面上项目资助(41576157) 上海市卫计委新百人计划项目资助(XBR2013111) 上海市优秀学术带头人计划项目资助(15XD1504600)
【分类号】：R914.5

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