基于药物-磷脂复合物的纳米释药系统研究进展

发布时间：2018-05-29 13:59

本文选题：药物-磷脂复合物 + 纳米释药系统　；参考：《国际药学研究杂志》2017年01期

【摘要】：磷脂是体内生物膜的主要成分,将其与药物复合形成药物-磷脂复合物,可改善药物的溶解性和稳定性,提高生物利用度。在此基础上,以药物-磷脂复合物为中间载体进一步构建的纳米释药系统成为近年来药剂学领域的研究热点。该类纳米释药系统兼具药物-磷脂复合物和纳米制剂的双重特点,既能提高药物的溶解性、稳定性和生物利用度,也可实现靶向给药,减少用药剂量,降低毒副作用,因此应用前景广阔。本文对药物-磷脂复合物组成结构、特点、形成机制以及基于药物-磷脂复合物构建的各类纳米释药系统的研究进展进行综述。
[Abstract]:Phospholipid is the main component of biofilm in vivo. The combination of phospholipids and drugs to form drug-phospholipid complex can improve the solubility and stability of drugs and increase the bioavailability. On this basis, drug-phospholipid complex as the intermediate carrier to further build a drug delivery system has become a research hotspot in the field of pharmacy in recent years. This kind of nano-drug delivery system has the dual characteristics of drug-phospholipid complex and nanometer preparation, which can not only improve the solubility, stability and bioavailability of drugs, but also achieve targeted drug delivery, reduce the dosage of drugs and reduce the side effects. Therefore, the application prospect is broad. In this paper, the structure, characteristics, formation mechanism of drug-phospholipid complex and the research progress of various nano-drug delivery systems based on drug-phospholipid complex are reviewed.
【作者单位】：中国医学科学院北京协和医学院药物研究所药物制剂研究室;军事医学科学院毒物药物研究所药物制剂研究室;
【分类号】：R943

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