曲安奈德在聚丙烯酸酯压敏胶中稳定性研究

发布时间：2018-05-30 00:46

本文选题：曲安奈德 + 聚丙烯酸酯压敏胶　；参考：《大连理工大学学报》2017年05期

【摘要】：曲安奈德是一种用于治疗皮肤炎症的中长效糖皮质激素.采用高效液相色谱-二极管阵列检测器(HPLC-DAD),考察了曲安奈德在强酸、强碱、强氧化剂强制降解条件下的稳定性,以及与几种常用聚丙烯酸酯压敏胶的相容性.结果发现,曲安奈德在酸性和氧化性条件下,实验后测定含量分别为100.02%和92.47%,而在碱性条件下完全降解.曲安奈德与压敏胶DURO-TAK汶87-2510、87-4098、87-2051配伍时稳定,而与DURO-TAK汶87-2677、87-2852或87-2516配伍时含量显著降低(分别为70.96%、80.38%和6.53%),但各检测波长下未见有关物质生成.参照各国药典,进一步使用液相色谱-高分辨质谱联用(LC-HRMS)技术分析样品中的有关物质,未见已收载的各有关物质.比较实验中所用各种聚丙烯酸酯压敏胶的特性,推测这种现象可能与DURO-TAK汶87-2677、87-2852和87-2516中存在的交联剂有关.
[Abstract]:Triamcinolone acetonide is a medium-term glucocorticoid used to treat skin inflammation. The stability of triamcinolone acetonide in strong acid, strong base and strong oxidant was investigated by high performance liquid chromatography-diode array detector (HPLC-DAD). The stability and compatibility of triamcinolone acetonide with several commonly used polyacrylate pressure sensitive adhesives were investigated. The results showed that the content of triamcinolone acetonide was 100.02% and 92.47% respectively in acidic and oxidizing conditions, but completely degraded in alkaline condition. Triamcinolone acetonide was stable in combination with pressure sensitive adhesive DURO-TAK Wen 87-2510C 87-409887-2051, but the content of triamcinolone acetonide with DURO-TAK Wen 87-2677-2852 or 87-2516 decreased significantly (70.960.38% and 6.53%, respectively). With reference to the pharmacopoeia of various countries, the LC-HRMS technique was further used to analyze the related substances in the samples, and no related substances were found in the samples. By comparing the properties of various polyacrylate pressure sensitive adhesives used in the experiment, it is suggested that this phenomenon may be related to the existence of crosslinkers in DURO-TAK Wen 87-2677, 87-2852 and 87-2516.
【作者单位】：大连理工大学制药科学与技术学院;大连理工大学化学分析测试中心;大连理工大学精细化工国家重点实验室;
【基金】：辽宁省自然科学基金优秀人才培育计划资助项目(2014020015)
【分类号】：R943

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