盐酸头孢吡肟的合成

发布时间：2018-05-30 06:06

  本文选题：盐酸头孢吡肟 + 抗生素　； 参考：《齐鲁药事》2012年02期

【摘要】：以7-ACA为起始原料,在环己烷中用六甲基二硅氨烷(HMDS)和三甲基碘硅烷(TMSI)将7-ACA中的氨基和羧基硅烷化,然后与N-甲基吡咯(NMP)和TMSI的反应产物混合,生成(6R,7R)-7-氨基-3-[(1-甲基-1-吡咯烷摀盐)甲基]头孢-3-烯-4-羧酸氢碘酸盐(中间体Ⅱ),再与活性酯反应得到盐酸头孢吡肟。
[Abstract]:Using 7-ACA as the starting material, the amino and carboxyl silanes in 7-ACA were synthesized by using hexamethyldisilyl (HMDS) and trimethyl iodiosilane (Ti) in cyclohexane, and then mixed with the reaction products of N-methylpyrrole (NMP) and TMSI. Cefpyridoxime hydrochloride was obtained by the reaction of ~ (6) R ~ + -7R ~ + -7- amino -3- [1-methyl-1-pyrrolidine] methyl] cef-3-ene-4-carboxylic acid hydroiodate (intermediate 鈪，

本文编号：1954209