温度和制备速度对聚桂醇泡沫稳定性的影响

发布时间：2018-06-01 23:37

本文选题：聚桂醇 + 泡沫硬化剂　；参考：《山东大学》2017年硕士论文

【摘要】：背景:脉管畸形好发于颈面部,是一种由于胚胎时期脉管的错误发育而形成的血管或者淋巴管系统的先天性疾病。依据构成脉管畸形的管道成分的不同又分为淋巴管畸形、微静脉畸形、静脉畸形、动脉畸形、动静脉畸形以及混合畸形。随着科学技术发展和药物的研发,脉管畸形的治疗方法丰富多样,现阶段临床常用的治疗方法有手术切除、激光照射、硬化治疗及多种方式的联合治疗等。近年来,泡沫硬化剂血注射因其具有操作简单、疗效佳的特点,逐渐成为脉管畸形的重要治疗方法。与传统的液体硬化剂相比,泡沫硬化剂因其具有泡沫性,从而临床应用中具有硬化剂用量少,硬化作用时间长,疗效显著,并发症少等优点。泡沫硬化剂的稳定性对其硬化效果具有重要影响,并与术后相关并发症的产生有重要关系。泡沫硬化剂的稳定性问题得到了临床医生的关注。大量研究发现,泡沫硬化剂稳定性与硬化剂性质、制备方法、液气比等因素有关,有学者研究发现低温可以增加泡沫的稳定性;泡沫的制备速度可能与硬化剂的稳定性有关。聚桂醇注射液作为临床治疗中广泛用于制作泡沫硬化剂的药物,其制备的泡沫稳定性与临床治疗效果有重要联系,但温度和制备速度与聚桂醇泡沫的稳定性的关系尚不明确。目的:1.通过研究不同温度下聚桂醇泡沫的半衰期变化情况,探讨温度变化对泡沫硬化剂稳定性的影响。通过对泡沫制备前行温度处理与泡沫制备后行温度处理所获的泡沫半衰期值进行统计分析,研究温度处理方式对泡沫硬化剂稳定性的影响。2.通过研究不同制备速度获得的泡沫半衰期的变化情况,探讨制备速度与泡沫硬化剂稳定性的相关性。方法:1.温度变化对聚桂醇泡沫稳定性的影响将实验分为2组:预处理组—将盛有聚桂醇注射液的注射器及盛有空气的注射器通过医用三通管连接后,置于不同温度中(5、15、25、35、45、55和65℃),预处理10min后,根据Tessari法制备聚桂醇泡沫。记录泡沫在室温(T=25℃)条件下的半衰期;后处理组—先在室温条件下制备聚桂醇泡沫,然后记录泡沫在不同温度下(5、15、25、35、45、55和65℃)的半衰期。利用SPSS 19.0软件包进行统计学分析,应用Pearson相关性检验,分析各处理组中温度与泡沫半衰期的相关性;并采用独立样本t检验研究2组之间即温度处理方式对泡沫半衰期的影响。2.制备速度对聚桂醇泡沫稳定性的影响将盛有聚桂醇注射液的注射器及盛有空气的注射器通过三通管连接,选用5组不同的推注速度在室温下制备聚桂醇泡沫,并记录环境温度为25℃条件下的泡沫半衰期值,利用SPSS 19.0软件包进行统计学分析,通过Pearson相关性检验,分析泡沫制备速度对泡沫稳定性的影响。结果:1.在预处理组和后处理组中,温度变化与聚桂醇泡沫的半衰期之间均存在负相关性(预处理组:r =-0.984,P0.05;后处理组:r=-0.969,P0.05)。T=25℃时,预处理组与后处理组之间的泡沫半衰期无显著差异(P=0.4280.05);T25℃时,预处理组半衰期高于后处理组;T25℃时,预处理组半衰期低于后处理组,差异具有显著性(P0.05)。2.不同制备速度获得的硬化剂泡沫的半衰期存在差异,通过统计学分析发现,随着制备速度的增加,泡沫的半衰期逐渐增加(r =0.983,P0.05)。当推注速度达到本实验最大值(10s/20次)时,硬化剂泡沫的半衰期最长。结论:1.温度是影响聚桂醇泡沫稳定性的一个重要因素,低温预处理和低温环境均可以提高泡沫的稳定性;泡沫制备前的温度与制备后的环境温度对泡沫稳定性的影响存在差异。2.硬化剂泡沫的制备速度对其稳定性具有显著影响,增加制备速度可以提高硬化剂泡沫的稳定性。
[Abstract]:Background: vascular malformation occurs well in the neck and face. It is a congenital disease of the vascular or lymphatic system caused by the incorrect development of the vasculature in the embryonic period. According to the different components of the vascular malformation, it is divided into lymphatic malformation, microvenous malformation, venous malformation, arteriovenous malformation, arteriovenous malformation, and mixed malformation. With the development of science and technology and drug development, the treatment methods of vascular malformation are rich and varied. At the present stage, the commonly used clinical treatment methods are surgical excision, laser irradiation, sclerotherapy and multiple ways of combined treatment. In recent years, the blood injection of foam sclerosing agent has gradually become an important part of the vascular malformation because of its simple operation and good curative effect. Compared with the traditional liquid sclerosing agent, the foam sclerosing agent has the advantages of little dosage of sclerosing agent, long hardening time, significant effect and less complications in clinical application. The stability of the foam sclerosing agent has an important influence on its hardening effect and is important to the production of related complications after the operation. A large number of studies have found that the stability of the foam sclerosing agent is related to the properties of the sclerosing agent, the preparation method, the ratio of liquid to gas, and other factors. Some scholars have found that low temperature can increase the stability of the foam; the preparation speed of the foam may be related to the stability of the sclerosing agent. Polyol injection As a drug widely used in the preparation of foamy sclerosing agents in clinical treatment, the stability of the prepared foam is closely related to the effect of clinical treatment, but the relationship between temperature and preparation speed and the stability of polyol foam is not clear. Objective: 1. the change of the half-life of polyol foam at different temperatures was studied and the temperature change was discussed. Influence on the stability of foamed sclerosing agent. By statistical analysis of the half-life value of foam by temperature treatment and foam preparation after preparation of foam, the influence of temperature treatment on the stability of the foam hardening agent.2. is discussed by studying the change of the half life of foam by studying the different preparation speed. The correlation between the preparation speed and the stability of the foam sclerosing agent. Methods: the effects of 1. temperature changes on the stability of polyol foam were divided into 2 groups: the pretreatment group - the syringes of the polyol injection and the syringes filled with air were connected through the medical three tube, and were placed at different temperatures (5,15,25,35,45,55 and 65 degrees C) and pretreated 1 After 0min, polyol foam was prepared by Tessari method. The half-life of foam at room temperature (T=25) was recorded. The post treatment group first prepared polyol foam at room temperature, and then recorded the half-life of foam at different temperatures (5,15,25,35,45,55 and 65 C). Statistical analysis was carried out by SPSS 19 software package, and Pearson correlation was applied. Test, the correlation between temperature and foam half life in each treatment group was analyzed, and an independent sample t test was used to study the effect of temperature treatment between 2 groups on the half-life of foam. The effect of.2. preparation speed on the stability of polyol foam would be connected by the syringe of the polyol injection and the syringe with the air in the three tube. Polyol foams were prepared at room temperature with 5 different groups of push and injection at room temperature, and the half-life value of the foam was recorded at ambient temperature of 25. SPSS 19 software package was used for statistical analysis. The effect of foam preparation speed on foam stability was analyzed by Pearson correlation test. Results: 1. in the pretreatment group and the post treatment group, temperature There was a negative correlation between the change and the half-life of polyol foam (pre treatment group: R =-0.984, P0.05; r=-0.969, P0.05) at.T=25 C, there was no significant difference in the half life of the foam between the pretreatment group and the post treatment group (P=0.4280.05); at T25, the half life of the pre treated group was higher than that of the post treatment group; at T25, the half-life of the pretreated group was low. In the post treatment group, the half-life of the sclerosing agent of the different preparation speed of the difference (P0.05).2. was different. Through statistical analysis, the half-life of the foam increased gradually (R =0.983, P0.05) with the increase of preparation speed. The half-life of the sclerosing agent when the injection velocity reached the maximum value of the experiment (10s/20 times). Conclusion: 1. temperature is an important factor affecting the stability of polyol foam. Low temperature pretreatment and low temperature environment can improve the stability of foam. There is a difference between the temperature of the foam before preparation and the ambient temperature of the prepared foam on the stability of the foam. The preparation speed of the.2. sclerosing agent has a significant influence on the stability of the foam. Increasing the speed of preparation can improve the stability of hardener foam.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R943

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