我院994例喹硫平血药浓度日常检测及药师干预分析

发布时间：2018-06-02 02:10

  本文选题：血药浓度 + 日常检测　； 参考：《中国药房》2015年08期

【摘要】：目的:为临床合理使用喹硫平提供参考。方法:对我院2013年994例喹硫平血药浓度检测结果按照患者性别、年龄、服用剂量分组,利用Excel统计不同组别的平均服用剂量和平均血药浓度,计算平均血药浓度与平均服用剂量的比值。并举例分析药师对血药浓度异常值的干预方法。结果:≤20岁、21~40岁、41~60岁、60岁组患者总体喹硫平血药浓度与服药剂量比值分别为0.78、0.76、1.04、1.21,呈逐渐增加趋势。喹硫平服药剂量在0~150、150~300、300~450、450~600、600~750、750~900 mg/d范围内,其血药浓度与服药剂量比值分别为2.24、1.38、0.96、0.88、0.82、0.50,随着服药剂量的增加,浓度剂量比降低,并且随着剂量增加,浓度剂量比值越接近。性别不影响喹硫平的血药浓度。结论:通过定期分析血药浓度和药师干预,能够使喹硫平的使用更趋合理。
[Abstract]:Objective: to provide reference for the rational use of quinolipine in clinic. Methods: 994 patients with quetiapine in our hospital in 2013 were divided into three groups according to their sex, age and dosage. Excel was used to calculate the average dose and average blood concentration of quetiapine in different groups. The ratio of mean blood concentration to average dose was calculated. An example was given to analyze the intervention methods of pharmacists on the abnormal value of serum drug concentration. Results: the total blood concentration and dose ratio of quetiapine in patients with 鈮，

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