跨血脑屏障纳米给药系统载体的研究进展

发布时间：2018-06-03 01:01

本文选题：脑部疾病 + 血脑屏障　；参考：《中国药房》2017年19期

【摘要】：目的:为深入研究和开发治疗脑部疾病的药物提供参考。方法:以"血脑屏障""纳米给药系统""脑靶向""纳米药物""载体""Blood brain barrier""Brain targeting""Drug delivery system""Nanomedicine""Carrier"等为关键词,组合查询2001-2016年在Pub Med、Elsevier、中国知网、万方、维普等数据库中的相关文献,对跨血脑屏障(BBB)纳米给药系统载体的研究成果进行综述。结果与结论:共检索到相关文献242篇,其中有效文献26篇。脑靶向纳米给药系统的常用载体有脂质体、聚合物胶束、聚合物纳米粒、树枝状聚合物及固体脂质纳米粒。将脑靶向纳米载体系统用于脑部疾病对于诊断和治疗疾病意义重大,其能在一定程度上克服BBB阻碍作用,有很好的应用前景。但脑靶向纳米给药系统大多数仍停留在基础研究层面,在研究中仍存在着多种问题。今后应寻找BBB选择性更高的作用靶点,研发高效、低毒的跨BBB纳米药物。
[Abstract]:Objective: to provide a reference for the further study and development of drugs for the treatment of brain diseases. Methods: using "blood brain barrier", "nanometer drug delivery system", "brain targeting", "nano-drug" carrier, "Blood brain barrier," Brain targeting, "Drug delivery system," Nanomedicine, "Carrier" as keywords, the relevant documents in Pub Meden Elsevier, China knowledge Network, Wanfang, Weip, etc., from 2001 to 2016, were selected. The research results of BBB nanoparticles delivery system were reviewed. Results & conclusion: a total of 242 literatures were retrieved, of which 26 were valid. The commonly used carriers of brain targeting drug delivery system include liposomes, polymer micelles, polymer nanoparticles, dendritic polymers and solid lipid nanoparticles. The application of brain-targeted nano-carrier system in the diagnosis and treatment of brain diseases is of great significance. It can overcome the obstacle of BBB to a certain extent and has a good application prospect. However, most of the brain targeting nanopharmaceutical delivery systems still remain at the basic level, and there are still many problems in the research. In the future, we should look for a more selective target of BBB and develop high efficiency, low toxicity cross-BBB nanopharmaceuticals.
【作者单位】：哈尔滨商业大学药学院;
【基金】：国家自然科学基金面上项目(No.81673871) 黑龙江省应用技术研究与开发计划项目(No.GC13C106) 哈尔滨市应用技术研究与开发项目(No.2016RQQXJ095) 2016年哈尔滨商业大学青年创新人才支持项目(No.2016QN076)
【分类号】：R943

【相似文献】