聚维酮碘的特性与临床应用

发布时间：2018-06-03 01:06

本文选题：聚维酮碘 + 理化特性　；参考：《中华医院感染学杂志》2016年03期

【摘要】：目的分析研究聚维酮碘(PVP-I)的理化性质、水溶液稳定性特点及其在临床上的应用效果,为降低患者手术后切口感染率提供理论依据。方法热加速试验法分析不同状态PVP-I水溶液的稳定性,并通过定量杀菌试验证实PVP-I杀菌的有效性。结果通过悬液定量杀菌试验证实,0.1~1.0g/L有效碘含量的PVP-I溶液能在1min内杀灭99.9%以上致病性酵母菌、99.9%以上的肠道致病菌和酿脓链球菌,但10g/L有效碘含量的PVP-I溶液则需要延长作用时间;由于稀PVP-I溶液有效碘含量低,在杀菌过程中被脓性物质、分泌物、血清等有机物消耗,因此必须保证足够的含量或延长作用时间,高浓度、低pH的溶液,在对碘封闭性好的容器中存放,PVP-I溶液表现出更好的稳定性。结论 PVP-I水溶液实际为一个动态平衡体系,体系中任一组分浓度的变化均导致平衡发生移动,稳定性发生变化,由于PVP-I水溶液性质温和,杀菌性能快速有效,均在临床上具有广泛的应用。
[Abstract]:Objective to study the physicochemical properties, stability characteristics of PVP-I and its clinical application in order to provide a theoretical basis for reducing the incision infection rate. Methods the stability of PVP-I aqueous solution in different states was analyzed by thermal accelerated test, and the effectiveness of PVP-I sterilization was proved by quantitative germicidal test. Results the suspension quantitative germicidal test confirmed that the PVP-I solution containing 0.1 渭 g / L effective iodine could kill more than 99.9% of intestinal pathogenic bacteria and Streptococcus pyogenes in 1min, but the PVP-I solution with 10g/L effective iodine content needed to prolong the time of action. Due to the low effective iodine content in dilute PVP-I solution and the consumption of purulent substances, secretions, serum and other organic substances during sterilization, it is necessary to ensure sufficient content or prolong the time of action, high concentration, low pH solution, etc. The storage of PVP-I solution in a container with good iodine sealing shows better stability. Conclusion the PVP-I aqueous solution is actually a dynamic equilibrium system. The change of the concentration of any component in the system leads to the shift of the equilibrium and the change of the stability. Because of the mild nature of the PVP-I aqueous solution, the bactericidal property of the aqueous solution is fast and effective. They are widely used in clinic.
【作者单位】：解放军第一医院药剂科;解放军第25医院药剂科;
【基金】：甘肃省中医药管理局基金项目(GZK-2012-49)
【分类号】：R961

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