水溶性水飞蓟素对大鼠体内卡马西平药动学的影响研究

发布时间：2018-06-03 16:43

  本文选题：水溶性水飞蓟素 + 卡马西平　； 参考：《中国药房》2015年01期

【摘要】：目的:研究水溶性水飞蓟素对大鼠体内卡马西平(CBZ)药动学的影响。方法:取18只大鼠随机均分为对照组(生理氯化钠溶液)、水溶性水飞蓟素普通剂量(50 mg/kg)组、水溶性水飞蓟素高剂量(100 mg/kg)组,灌胃给予相应药物,每日1次,连续给药7 d,末次给药1 h后所有大鼠灌胃给予CBZ 50 mg/kg。分别于给药前及给予CBZ后0.5、1、1.5、2、4、6、8、10、12 h眼眶取血,以地西泮为内标,以高效液相色谱法测定血浆中CBZ及其代谢产物10,11-环氧卡马西平(ECBZ)的浓度,并利用Win Nolin 5.2药动学软件计算药动学参数。结果:与对照组比较,水溶性水飞蓟素普通剂量组和水溶性水飞蓟素高剂量组大鼠体内CBZ的Ka明显增加[(0.31±0.22)vs.(2.66±3.12)、(5.26±4.58)h-1,P0.05],ECBZ的AUC0-12 h[(53.87±7.31)vs.(70.65±12.79)、(68.44±4.62)mg·h/L,P0.05]、cmax[(7.20±0.87)vs.(8.82±0.54)、(8.19±0.38)mg/L,P0.05]明显增加,其余药动学参数比较差异无统计学意义。结论:水溶性水飞蓟素连续服用可促进CBZ在大鼠体内的吸收,同时有促进CBZ体内代谢的趋势,临床上两者合用时应注意潜在的药物相互作用。
[Abstract]:Aim: to study the effect of water soluble silymarin on the pharmacokinetics of carbamazepine (CBZ) in rats. Methods: eighteen rats were randomly divided into control group (physiological sodium chloride solution, water soluble silymarin 50 mg / kg) group and water soluble silymarin high dose (100 mg / kg) group. All the rats were given CBZ 50 mg / kg by gavage 1 h after the last administration for 7 days. The concentrations of CBZ and its metabolite 10BZ in plasma were determined by HPLC with diazepam as internal standard before and after administration of CBZ. The pharmacokinetic parameters were calculated by Win Nolin 5.2 pharmacokinetic software. 缁撴灉:涓庡�圭収缁勬瘮杈�,姘存憾鎬ф按椋炶摕绱犳櫘閫氬墏閲忕粍鍜屾按婧舵，

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