延胡索甲素与左旋延胡索乙素抗吗啡躯体依赖和精神依赖的作用研究

发布时间：2018-06-04 17:36

本文选题：延胡索甲素 + 左旋延胡索乙素　；参考：《药物评价研究》2016年02期

【摘要】：目的观察并比较延胡索甲素(corydaline,Cor)与左旋延胡索乙素(l-tetrahydropalmatine,l-THP)抗吗啡躯体依赖和精神依赖的作用。方法 SD大鼠随机分为对照组、模型组、Cor组、l-THP组。连续递增sc吗啡9 d后,纳洛酮促瘾,制备吗啡依赖大鼠催促戒断模型,促瘾前30 min ip Cor(40、80 mg/kg)或l-THP(5.0、10.0 mg/kg),观察大鼠戒断症状和体质量的降低;应用旷场实验,观察Cor(5、10 mg/kg)和l-THP(2.5、5.0 mg/kg)对吗啡诱导的大鼠自发活动的影响、对吗啡连续递增给药致大鼠行为敏化效应的影响,以及Cor(10、20、40 mg/kg)和l-THP(2.5、5.0、10.0 mg/kg)对大鼠自发活动的影响。结果 Cor(40、80 mg/kg)、l-THP(5.0 mg/kg)对吗啡催促戒断症状无显著改善作用,10 mg/kg l-THP显著改善大鼠戒断症状(P0.05);Cor和l-THP对吗啡降低大鼠体质量效应有改善趋势,但差异不显著;Cor 40 mg/kg以下剂量、l-THP 10 mg/kg以下剂量对大鼠自发活动无显著影响;Cor(5、10 mg/kg)和l-THP(2.5、5.0 mg/kg)均可显著降低吗啡诱发的大鼠高活动性行为、行为敏化的形成(P0.05、0.01)。结论 Cor和l-THP对吗啡所致的大鼠躯体依赖和精神依赖均有不同程度的调节作用,l-THP的起效剂量明显低于Cor。
[Abstract]:Objective to observe and compare the effects of Corydalis corydalis Corr) and L-tetrahydropalmatine l-THP on morphine somatic dependence and mental dependence. Methods SD rats were randomly divided into control group and model group. After 9 days of continuous increase of sc morphine, naloxone induced withdrawal in morphine dependent rats. The withdrawal model was induced by morphine dependence in rats. The withdrawal symptoms and body mass of the rats were observed by open field experiment, and the withdrawal symptoms and body mass of the rats were observed by 30 min IP Corn 4080 mg / kg or l-THPX 5.0 mg / kg. The effects of 10 mg / kg (10 mg / kg) and 2.55 mg / kg of l-THPN) on the spontaneous activity induced by morphine, on behavioral sensitization of rats induced by continuous increasing morphine administration, and on the effects of Corn 1020 ~ (40 mg / kg) and l-THPN 2.55.0 mg / kg) on the spontaneous activity of rats were observed. Results Corn 4080 mg 路kg ~ (-1) h ~ (-1) T _ (5) mg 路kg ~ (-1) had no significant improvement on morphine precipitated withdrawal symptoms. After 10 mg/kg l-THP, the effects of P0.05Cor and l-THP on the decrease of body mass of morphine in rats were significantly improved. However, there was no significant difference between different doses of Cor 40 mg/kg and THP 10 mg/kg on the spontaneous activity of rats. Both the dose of Cor 40 mg/kg and the dose below 10 mg / kg of l-THPN 2. 5 mg / kg could significantly decrease the high activity behavior induced by morphine and the formation of behavioral sensitization in rats (P0.050.01). Conclusion both Cor and l-THP have different regulatory effects on morphine induced somatic and mental dependence in rats. The onset dose of l-THP is significantly lower than that of Coral.
【作者单位】：广东药学院中药学院;军事医学科学院毒物药物研究所抗毒药物与毒理学国家重点实验室国家北京药物安全评价研究中心;广东药学院实验动物中心;
【基金】：重大新药创制科技重大专项(2013ZX09302303);重大新药创制科技重大专项(2012ZX09301003-001-008) 北京市科委基金项目(Z131100006513010)
【分类号】：R965

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