基于毒性通路扰动的药物安全性评价新策略

发布时间：2018-06-08 14:42

本文选题：药物发现 + 药物评价　；参考：《中国药理学与毒理学杂志》2015年03期

【摘要】：安全性是决定创新药物研发成败的关键因素。传统的药物毒性测试与安全性预测面临严峻挑战。基于毒性通路扰动的毒性测试策略已成为药物安全性评价的重要发展方向。本文针对传统毒性测试方法存在的问题,简要介绍了毒性通路的内涵及其毒理学意义,重点阐述了基于毒性通路扰动的安全性评价新策略的提出及其发展,并以药物线粒体毒性预测为例,介绍了毒性测试新策略的原理及应用,为药物安全性评价的发展提供新的思路。
[Abstract]:Safety is the key factor to determine the success or failure of innovative drug development. Traditional drug toxicity testing and safety prediction are facing severe challenges. Toxicity test strategy based on toxicity path disturbance has become an important development direction of drug safety evaluation. In this paper, the connotation and toxicological significance of toxic pathway are briefly introduced, and the new strategy of safety evaluation based on disturbance of toxic pathway is discussed in detail. Taking the prediction of drug mitochondrial toxicity as an example, this paper introduces the principle and application of the new strategy of toxicity test, which provides a new way of thinking for the development of drug safety evaluation.
【作者单位】：军事医学科学院疾病预防控制所毒理学评价研究中心;
【基金】：国家自然科学基金重点项目(81430090) 联合利华国际合作课题(CH-2011-1318)~~
【分类号】：R96

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