药物入壶后输出液药物浓度峰值的影响因素

发布时间：2018-06-09 23:11

本文选题：药物浓度 + 峰值浓度　；参考：《中国医院药学杂志》2015年02期

【摘要】：目的:探索药物入壶后输出液药物浓度峰值变化规律并分析其影响因素,为临床规范应用这一给药方式提供理论依据。方法:用紫外可见光光度仪连续监测龙胆紫饱和溶液入壶后输出液体的吸光度,将测得的吸光度转换成药物浓度,获得输出液药物浓度峰值。分别设定输液速度为90,180,360,720 ml·h-1;输液器滴壶内液体量分别设定为2,3,4 ml;入壶溶液分别为1,2 ml。对实验结果进行统计学分析。结果:输液速度(x1)、滴壶内液体量(x2)、入壶药量(x3)对输出液药物浓度峰值(y)均有影响,差异具有统计学意义(P0.05)。对于3个影响因素的多元线性回归分析得到^y=7.283+0.003 x1-1.904x2+8.820 x3(R2=0.947,F=547.080),三者影响由大到小依次为:入壶药量、壶内液量、输液速度。入壶药量越大,输出液药物浓度峰值越高,壶内液量越多输出液药物浓度峰值越低,输液速度越快输出液药物浓度峰值越高。结论:入壶给药时输出液药物浓度受多种因素影响,与静脉注射药物浓度变化规律不同,一些药物不能采用入壶方式代替静脉注射。
[Abstract]:Objective: to explore the change rule of the peak concentration of the drug in the exported solution after the medicine was put into the pot and analyze its influencing factors, and to provide the theoretical basis for the clinical standard application of the drug. Methods: UV-vis spectrophotometer was used to continuously monitor the absorbance of the liquid after the saturated solution of Gentian Violet was put into the pot. The absorbance was converted into the drug concentration and the peak value of the drug concentration was obtained. The infusion rate was set at 90180360720 ml h-1, the volume of liquid in the infusion pot was set at 2 ~ 3 ~ 4 ml, and that in the pot was 1 ~ 2 ml. The experimental results were analyzed statistically. Results: the rate of infusion (x 1), the volume of liquid in the pot (x 2) and the amount of medicine in the pot (x 3) all affected the peak value of the drug concentration in the export solution (P 0.05), and the difference was statistically significant (P < 0.05). For the three influencing factors, the multiple linear regression analysis showed that the three influencing factors were 7.283 0.003 x1-1.904x2 8.820 x 3N R2O 0.947 FN 547.080, the order of the three effects from big to small was as follows: the quantity of medicine into pot, the quantity of liquid in pot, and the velocity of infusion. The higher the amount of medicine into the pot, the higher the peak value of the drug concentration in the output liquid, the lower the peak value of the drug concentration in the output liquid, the higher the velocity of infusion, the higher the peak value of the drug concentration in the output liquid. Conclusion: the concentration of the exported solution is affected by many factors, which is different from that of intravenous injection. Some drugs can not be used as a substitute for intravenous injection.
【作者单位】：河北医科大学第三医院;北京铁路局石家庄卫生防疫站;
【基金】：河北省2010年医学科学研究重点课题计划(20100362)
【分类号】：R969

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