单唾液酸四己糖神经节苷脂钠注射液致不良反应56例文献分析

发布时间：2018-06-10 02:14

  本文选题：单唾液酸四己糖神经节苷脂钠注射液 + 不良反应　； 参考：《中国药房》2016年08期

【摘要】：目的:探讨单唾液酸四己糖神经节苷脂钠注射液致不良反应(ADR)发生的特点、一般规律及相关风险因素,为临床安全用药提供参考。方法:以"单唾液酸四己糖神经节苷脂""不良反应"等为检索词,检索相关期刊论文、万方数据库、维普中文科技期刊数据库自数据库最早收录的时间至2014年10月,按纳入与排除标准进行文献筛选,对得到的病例资料进行提取和统计分析。结果:共纳入19篇文献,涉及56例患者,其中男、女性别比例为6.17∶1,0~9、≥60岁患者居多,各有25、17例(分别占44.64%、30.36%);ADR可累及多个器官/系统,以发热(29例)、寒战(28例)最为常见,严重者可致格林-巴利综合征、过敏性休克等。结论:临床应重视单唾液酸四己糖神经节苷脂钠注射液引发的ADR,密切防范ADR的发生,生产企业应尽快完善说明书,确保临床用药安全。
[Abstract]:Objective: to investigate the characteristics, general rules and related risk factors of adverse reactions induced by sodium sialate tetrahexose ganglioside injection in order to provide reference for safe drug use. Methods: using "tetrahexosylganglioside monsialate" and "adverse reaction" as the key words, the Chinese journal full-text database, Wanfang database and Weipu Chinese scientific and technological journal database were searched from the earliest date of the database to October 2014. According to the inclusion and exclusion criteria for literature screening, the case data were extracted and statistically analyzed. Results: a total of 19 articles were included, including 56 cases involving 56 patients. The male / female ratio was 6.17: 1 / 0 / 9, and the majority was over 60 years old. There were 2517 cases in each group (44.64%, 30.36 6% ADR could involve multiple organs / systems, 29 cases were fever, 28 cases were shivering). Severe cases can cause Guillain-Barre syndrome, anaphylactic shock and so on. Conclusion: we should pay attention to ADR caused by sodium tetrahexose monoglycoside injection in clinic, prevent the occurrence of ADR closely, and improve the instructions as soon as possible to ensure the safety of clinical drug use.
【作者单位】： 开封市食品药品检验所;
【分类号】：R971
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本文编号：2001627