布地奈德缓释干粉吸入剂的制备及乳糖用量的影响

发布时间：2018-06-14 10:02

本文选题：布地奈德 + 壳聚糖　；参考：《药学学报》2015年09期

【摘要】：采用高压匀质联合喷雾干燥法制备载有布地奈德的壳聚糖微粒并考察其体外释放行为,用涡旋混合器使之与乳糖混合,以药物回收率和含量均匀度为指标考察混合速度与混合时间的影响,以药物回收率、含量均匀度、粉末流动性和体外沉积分布为指标考察乳糖用量的影响。制得微粒具有一定的体外缓释效果,可吸入组分百分比为46.0%,但流动性较差,加入10倍乳糖进行混合后,药物回收率高达96.5%,药物含量的相对标准偏差为2.5%,流动性较好,可吸入组分百分比提高至59.6%。结果表明,采用涡旋混合器可制备回收率及含量均匀度均较高的布地奈德缓释干粉吸入剂,处方具有较好的流动性,适于肺部吸入。
[Abstract]:The chitosan particles carrying budesonide were prepared by high pressure homogenization combined with spray drying, and their release behavior in vitro was investigated. The effect of mixing rate and mixing time on the rate of drug recovery and the mixing time was investigated by a vortex mixer. The drug recovery rate, the content uniformity, the powder fluidity and the outside in vitro were investigated. The deposition distribution is an index to investigate the effect of lactose content. The prepared particles have a certain in vitro release effect, and the percentage of inhalation components is 46%, but the fluidity is poor. After adding 10 times the lactose, the drug recovery rate is up to 96.5%, the relative standard deviation of the drug content is 2.5%, the fluidity is better, and the percentage of the inhalable component can be increased to 59. The results of.6%. show that the preparation of budesonide sustained-release dry powder inhalers with high recovery and high content uniformity can be prepared by using the vortex mixer. The formulation has good fluidity and is suitable for lung inhalation.
【作者单位】：沈阳药科大学药学院;Global
【基金】：德国拜耳集团项目资助 “辽宁省创新药物孵化平台建设”项目资助
【分类号】：R943

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