住院患者抗肿瘤药物超说明书用药医嘱点评方法探讨与应用评价

发布时间：2018-06-14 09:55

本文选题：抗肿瘤药物 + 超说明书用药　；参考：《中国医院药学杂志》2015年08期

【摘要】：目的:建立住院患者抗肿瘤药物超说明书用药医嘱点评方法,并将其应用于抗肿瘤药物用药合理性综合评价。方法:基于循证原则和文献方法,针对抗肿瘤药物使用过程中与超说明书应用相关的适应证、给药剂量、给药途径及给药顺序等主要指标建立了评价标准,这个评价标准还包含了抗肿瘤药物使用过程中其他合理用药的评价指标。依据建立的评价标准,随机抽取我院肿瘤内科住院患者2 050份病历,对抗肿瘤药物用药合理性进行综合评价,并根据点评结果积极干预临床用药。结果:点评结果显示,抗肿瘤药物的超说明书用药情况主要体现在化疗剂量不准确、给药途径不符合说明书规定或序贯给药顺序不恰当,未发现不符合适应证应用的情况;干预后,化疗剂量和给药顺序等超说明书用药相关指标得到明显改善。结论:建立了以超说明书用药为主要评价内容的抗肿瘤药物医嘱点评方法,制定的评价标准和调查表能够方便临床药师全面深入判断抗肿瘤药物在超说明书用药环节存在的问题,为进一步开展相关研究提供思路。
[Abstract]:Objective: to establish a method for evaluating the prescriptions of anti-tumor drugs in our hospital and to evaluate the rationality of anti-tumor drugs. Methods: based on evidence-based principles and literature methods, the evaluation criteria were established for the indications, dosage, route and sequence of administration of anti-tumor drugs. The criteria also include indicators for other rational use of anti-tumor drugs. According to the established evaluation criteria, 2050 medical records of inpatients in department of oncology in our hospital were randomly selected to evaluate the rationality of antitumor drugs, and to intervene in clinical medication according to the evaluation results. Results: the results showed that the overdose of anti-tumor drugs was mainly reflected in the inaccurate dosage of chemotherapy, the inappropriate route of administration or the sequence of sequential administration, and the failure to meet the indications. After intervention, the dosage and sequence of chemotherapy were significantly improved. Conclusion: an evaluation method of antitumor drug orders was established, which was mainly evaluated by superprescriptions. The evaluation criteria and questionnaire can facilitate clinical pharmacists to fully and thoroughly judge the problems existing in the over-specification of anti-tumor drugs, and provide ideas for further research.
【作者单位】：郑州大学第一附属医院药学部;
【分类号】：R95

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