头孢舒巴坦复合制剂对血流感染革兰阴性杆菌的体外抑菌效应

发布时间：2018-06-21 20:56

本文选题：头孢噻肟/舒巴坦 + 血流感染　；参考：《上海交通大学学报(医学版)》2015年02期

【摘要】：目的评估头孢舒巴坦复合制剂对引起血流感染的主要革兰阴性杆菌的体外抑菌效应。方法收集引起血流感染的产超广谱β-内酰胺酶(ESBLs)大肠埃希菌、非产ESBLs大肠埃希菌、产ESBLs肺炎克雷伯菌、非产ESBLs肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌各30株,采用琼脂平板二倍稀释法测定第三代复合制剂头孢噻肟/舒巴坦(CTX/SBT)、头孢曲松/舒巴坦(CRO/SBT)和头孢哌酮/舒巴坦(CPZ/SBT)及单方制剂头孢噻肟(CTX)、头孢曲松(CRO)、头孢哌酮(CPZ)的最低抑菌浓度(MIC),计算50%最低抑菌浓度(MIC50)。结果复合制剂的抑菌效应均优于单方制剂,MIC50的降幅可达4~8倍。CTX/SBT的抑菌效果优于CRO/SBT和CPZ/SBT,其对产ESBLs大肠埃希菌和肺炎克雷伯菌的MIC50降至32~64μg/m L,与CTX单药相比降低了8倍。结论 3种第三代头孢舒巴坦复合制剂对引起血流感染的主要革兰阴性杆菌的体外抑菌效果均优于单方制剂,其中CTX/SBT的抑菌效果最好,尤其是针对产ESBLs菌株。
[Abstract]:Objective to evaluate the bacteriostatic effect of cefsulbactam compound preparation on major gram-negative bacilli caused by blood flow infection in vitro. Methods Extended-spectrum 尾 -lactamase producing Escherichia coli, non-ESBLs-producing Escherichia coli, ESBLs-producing Klebsiella pneumoniae, non-ESBLs-producing Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii were collected. Determination of ceftaxime / sulbactam CTX / SBT, ceftriaxone / sulbactam cefoperazone / sulbactam (CPZ / SBT) and ceftaxime (CTX), ceftriaxone, cefazone (CPZ) by Agar plate double dilution method Low inhibitory concentration (MIC) was used to calculate the minimum inhibitory concentration (MIC) of 50%. Results the bacteriostatic effect of the compound preparation was better than that of the single compound preparation: the decrease of MIC50 was 4 ~ 8 times. The inhibitory effect of CTX / SBT was better than that of CRO / SBT and CPZ / SBT, and the MIC50 of compound preparation was reduced to 32 ~ 64 渭 g / m ~ (L) of ESBLs producing Escherichia coli and Klebsiella pneumoniae, which was 8 times lower than that of CTX single drug. Conclusion the in vitro bacteriostatic effects of the three third-generation Cefsulbactam compounds against the main gram-negative bacilli caused by blood flow infection were superior to those of the single formulation, and CTX / SBT was the best, especially for ESBLs-producing strains.
【作者单位】：上海交通大学医学院附属瑞金医院灼伤整形科;
【分类号】：R96

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