519例严重药品不良反应病例分析

发布时间：2018-06-22 02:01

本文选题：严重药品不良反应 + 分析　；参考：《中国医院药学杂志》2015年02期

【摘要】：目的:探讨严重药品不良反应(ADR)发生的临床特点和规律,为临床合理用药提供参考。方法:采用回顾性研究的方法,从国家药品不良反应监测系统安徽省药品不良反应监测中心2012年数据库中筛选出519例严重ADR病例,进行整理、统计与分析。结果:519例严重ADR病例中,40岁以上的中老年病人发生严重ADR的比例很高,占75.3%。引起严重ADR的药物中,排在前三位的依次是抗肿瘤药物153例(23.25%),抗生素118例(17.93%)和中药注射剂41例(6.23%)。合并使用多种药物是发生严重ADR的一个值得关注的危险因素。发生严重ADR的最常见给药途径是静脉给药,占76.75%。严重ADR发生时间差异较大,最短的为用药当天,甚至用药后几分钟,最长的993天。临床表现多样,大部分系统均有累及,累及系统-器官以全身性损害比例最高,其次是皮肤及其附件损害,大部分病例对症治疗后好转。结论:临床医务人员应该提高对严重ADR的认识,一旦发生ADR应积极采取对症治疗,避免进展为严重ADR,同时要加强ADR监测,提高合理用药水平。
[Abstract]:Objective: to investigate the clinical characteristics and regularity of severe adverse drug reactions (ADR), and to provide reference for rational drug use. Methods: 519 cases of severe ADR were selected from the data base of Anhui Provincial Center for Monitoring adverse Drug reactions (ADRs) in 2012 by retrospective study. Results among the 519 cases of severe ADR, the incidence of severe ADR in the middle and old aged patients over 40 years old was very high (75.3%). Among the drugs causing severe ADR, 153 cases (23.25%) were antitumor drugs, 118 cases (17.93%) were antibiotics and 41 cases (6.23%) were Chinese traditional medicine injections. Combined use of multiple drugs is a significant risk factor for severe ADR. The most common route of severe ADR is intravenous administration, which accounts for 76.75. There was a great difference in the occurrence time of severe ADR, the shortest was on the day of medication, even a few minutes after medication, and the longest time was 993 days. The clinical manifestations were diverse, most of the systems were involved, the proportion of systemic damage was the highest, followed by the skin and its adnexal damage, and most of the cases improved after symptomatic treatment. Conclusion: the clinical medical staff should improve their understanding of severe ADR, and should take active treatment to avoid the progression to severe ADR.The monitoring of ADR should be strengthened and the level of rational use of ADR should be raised at the same time.
【作者单位】：安徽省药品不良反应监测中心;安徽中医药大学;安徽中医药大学第一附属医院;
【分类号】：R95

【共引文献】