5种重金属暴露对秀丽线虫生物毒性效应效应的Meta回归分析

发布时间：2018-06-23 20:59

本文选题：重金属 + 生物毒性　；参考：《中国血吸虫病防治杂志》2016年02期

【摘要】：目的评价5种重金属暴露对秀丽线虫的生物毒性效应。方法以秀丽线虫、重金属等为关键词检索Pub Med、Web of Science、EBSCO、中国知网、万方等国内外数据库,检索时间为2004-01-2014-12,按照文献纳入和排除标准筛选关于镉(Cd)、汞(Hg)、铅(Pb)、砷(As)、铬(Cr)及铜(Cu)暴露对秀丽线虫毒性效应的文献。提取文献中相关数据,以秀丽线虫的毒性指标终点为因变量,不同金属种类、暴露浓度、暴露时间等为自变量,采用Meta回归分析比较5种重金属暴露对秀丽线虫的生物毒性效应。结果根据文献纳入和排除标准,最终筛选出有关Cu暴露对秀丽线虫生物毒性的文献10篇、有关Cr的文献12篇、有关Pb的文献12篇、有关Cd的文献10篇、有关As的文献3篇、有关Hg的文献14篇。Meta回归分析显示,以Cu为参照,5种重金属对秀丽线虫致死率排序为HgPbCrCdAs,回归模型校正决定系数为0.600 8;基于发育影响的体长指标、基于生殖毒性的世代时间指标、基于神经毒性的身体弯曲度指标和头部摆动频率指标的毒性效应排序均为HgPbCrCd,回归模型校正决定系数分别为0.888 4、0.538 6、0.698 6和0.747 1;根据LC_(50)指标,各重金属对线虫毒性效应排序为HgPbCrCdAs。敏感性分析显示,Meta回归分析结果较为稳定。结论Hg、Pb对秀丽线虫的生物毒性效应强于Cr、Cd和As。
[Abstract]:Objective to evaluate the biological toxicity of five heavy metals to nematode. Methods using nematode and heavy metal as the keywords, we searched the databases of Pub Meden Web of Science EBSCO, China Zhiwang, Wanfang and so on at home and abroad. The search time was 2014-12 from January to January 2004. According to the criteria of inclusion and exclusion, the literatures on the toxic effects of cadmium (CD), mercury (Hg), lead (Pb), arsenic (As), chromium (Cr) and copper (Cu) on nematodes were screened. The related data were extracted from the literature. The endpoint of toxicity index of nematode was regarded as dependent variable, different metal species, exposure concentration and exposure time were independent variables. Meta regression analysis was used to compare the biotoxicity of five heavy metals to nematodes. Results according to the criteria of inclusion and exclusion, 10 papers were selected on the biological toxicity of Cu exposure to nematode, 12 papers were about Cr, 12 articles were about Pb, 10 articles were about CD, 3 articles were about as. 14 references about Hg. Meta regression analysis showed that the fatality rate of 5 heavy metals in cu was HgPbCrCdAs. the calibration decision coefficient of regression model was 0.600 8, based on the developmental effect of body length index, based on reproductive toxicity of the generation time index. The toxicity order of body curvature index and head swinging frequency index based on neurotoxicity was HgPbCrCd2.The calibration decision coefficients of regression model were 0.888 ~ 0.538 6 ~ 0.698 6 and 0.747 ~ 1, respectively. According to LC50 index, the toxicity effect of heavy metals to nematode was HgPbCrCdAs. Sensitivity analysis showed that the results of Meta-regression analysis were stable. Conclusion the biotoxicity of Hgfen Pb to nematodes is stronger than that of Cr-CD and As.
【作者单位】：安徽理工大学地球与环境学院;皖南医学院公共卫生学院;皖南医学院基础医学院;安徽省芜湖市环境监测中心站;
【基金】：国家自然科学基金(81270091) 安徽省自然科学基金(1608085MH220) 活性生物大分子研究安徽省重点实验室项目(LAB201406) 安徽省芜湖市科技计划重点项目(2014cxy08)
【分类号】：R99

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