加强对碳青霉烯类抗菌药物使用管理的效果评价

发布时间：2018-06-24 23:30

本文选题：抗菌药物 + 碳青霉烯类药物　；参考：《中华医院感染学杂志》2017年08期

【摘要】：目的通过加强对碳青霉烯类抗菌药物的使用管理,评价管理后的临床效果。方法回顾性分析2016年1月1日-11月30日医院对碳青霉烯类抗菌药物使用管理前后出院患者抗菌药物使用率、患者的平均住院时间、经济学效益、患者的病死率等的变化情况。结果加强管理后总抗菌药物中位使用率分别为42.76%、43.38%,差异无统计学意义;中位碳青霉烯类药物使用率由4.27%降至2.53%(P0.05);加强管理前后中位平均住院日、人均抗菌药物使用日未见明显增加;中位人均抗菌药物费用较前有下降趋势,分别为1663.46元、1704.12元,差异无统计学意义;加强管理后抗菌药物费用占总费用及药品费用比例较前下降(P0.05);加强管理后使用抗菌药物患者病死率较前有下降趋势,差异无统计学意义。结论加强对碳青霉烯类抗菌药物使用管理显著降低碳青霉烯类药物的使用率,并在一定程度上降低了人均抗菌药物费用、病死率,但平均用药时间及平均住院日无明显变化。
[Abstract]:Objective to evaluate the clinical effect of carbapenem by strengthening the management of carbapenem antibiotics. Methods the utilization rate of antibiotics, the average hospitalization time, the economic benefit and the mortality of the discharged patients before and after the management of carbapenem antibiotics in hospital from January 1 to November 30, 2016 were analyzed retrospectively. Results the median utilization rate of total antimicrobial agents was 42.76 and 43.38, respectively, and the median utilization rate of carbapenem decreased from 4.27% to 2.53% (P0.05). The average cost of antimicrobial drugs in the median per capita was 1663.46 yuan or 1704.12 yuan, which had no statistical significance. The proportion of antimicrobial cost to total cost and drug cost decreased after strengthening management (P0.05); the mortality rate of patients with antimicrobial drug use after strengthening management decreased compared with the former, the difference was not statistically significant. Conclusion strengthening the management of carbapenem antimicrobial agents can significantly reduce the utilization rate of carbapenem drugs, and to some extent reduce the per capita antimicrobial cost and mortality, but there is no significant change in the average drug use time and average hospital stay.
【作者单位】：宁波市第二医院感染科;宁波市第二医院院感管理科;宁波市第二医院药学部;宁波市第二医院急诊科;宁波市第二医院肝病研究所;
【基金】：宁波市社发重大专项基金资助项目(2011C51002) 浙江省区域专病中心建设学科基金资助项目(2014-98) 浙江省自然科学基金资助项目(LY13H190008)
【分类号】：R954

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