某院泌尿外科门诊超说明书用药的现状与分析

发布时间：2018-06-25 09:46

  本文选题：泌尿外科 + 超说明书用药　； 参考：《中国医院药学杂志》2017年20期

【摘要】：目的:了解某院泌尿外科门诊超说明书用药情况,为临床合理用药提供科学依据,促进临床合理安全用药。方法:收集某院自2014年1月1日-2016年1月1日泌尿外科门诊处方,遴选出全部不符合药品说明书所规定的用药适应证,剂量以及频率的处方,进行相关统计分析。对照国内外相关指南、文献报道分析超说明书用药的合理性。结果:在所抽取的21 485张泌尿外科门诊处方中,有524张处方(2.4%)涉及超说明书用药,共涉及药品9种,均属于超适应证用药范畴,未出现超剂量、超用药频次以及超疗程用药的情况。超适应证用药共7项,均有相关证据支持,其中2项符合国外内指南用法;5项有相关的文献报道支持。在所有超说明书用药的处方中,α1-受体阻滞剂(坦索罗辛缓释胶囊、多沙唑嗪缓释片)所占比例最大(55.9%),所涉及的用药适应证是输尿管下段结石。结论:该院的泌尿外科门诊常见超说明书用药均有相关证据支持,使用基本合理,但证据质量存在差异。在临床实际工作中,临床药师应与处方医师充分协作,权衡超说明书用药的利弊,提高临床合理用药水平以及处方的合理性。
[Abstract]:Objective: to investigate the use of drugs in Urology outpatient department in order to provide scientific basis for rational use of drugs in clinic and promote rational and safe use of drugs in clinic. Methods: from January 1, 2014 to January 1, 2016, the outpatient prescriptions of urology in a hospital were collected, and the indications, doses and frequencies of drugs that did not conform to the drug instructions were selected for statistical analysis. Compared with domestic and foreign related guidelines, literature reports analyzed the rationality of drug use. Results: of the 21,485 urological outpatient prescriptions, 524 prescriptions (2.4%) were involved in superprescriptions, 9 kinds of drugs were involved, all of them belonged to the category of over-indications, and no overdose was found. The frequency of supermedication and the situation of drug use over the course of treatment. There were 7 overindications, all of which were supported by relevant evidence, of which 2 were in accordance with internal guidelines and 5 were supported by relevant literature reports. The 伪 1-receptor blocker (tansoloxin sustained-release capsule, doxazosin sustained-release tablet) accounted for the largest proportion (55.9%) among all the prescriptions of hyper-herbalism, and the indication involved was lower ureteral calculi. Conclusion: the common superprescriptions of Urology outpatient in our hospital are supported by relevant evidence, and the use is reasonable, but the quality of evidence is different. In clinical practice, clinical pharmacists should fully cooperate with prescription physicians to weigh the advantages and disadvantages of over-description of drugs and to improve the level of rational use of drugs in clinic and the rationality of prescriptions.
【作者单位】： 广州市番禺区何贤纪念医院药剂科;广州市番禺区何贤纪念医院泌尿外科;
【分类号】：R95
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本文编号：2065500