不同输液配伍葛根素注射液对溶血的影响

发布时间：2018-06-28 06:18

本文选题：葛根素注射液 + 溶血性　；参考：《中国医院药学杂志》2015年05期

【摘要】：目的:探讨葛根素注射液与临床上常用的2种输液配伍后对其溶血不良反应的影响。方法:采用分光光度法测定孵育1,3,6h时,葛根素不同浓度、不同输液配伍时的溶血率;测定溶液pH值、渗透压值,明确pH、渗透压、Na+、Cl-和葡萄糖分子在溶血中的作用。结果:葛根素注射液与不同输液配伍时,相同孵育时间、相同浓度的溶血率存在显著差异,组间pH值存在显著变化,而渗透压无显著变化,Na+、Cl-、葡萄糖分子能显著影响溶血率变化。结论:葛根素注射液与不同输液配伍后的溶血存在显著差异,pH值、渗透压不是引起溶血差异的因素;葛根素注射液与0.9%氯化钠注射液和5%葡萄糖注射液输液配伍时,红细胞对溶质成分Na+、Cl-、葡萄糖分子的膜通透性不同可能是引起溶血差异的主要原因。
[Abstract]:Objective: to investigate the effect of puerarin injection combined with two kinds of infusion fluids on adverse hemolysis. Methods: the hemolysis rate of puerarin in different concentration and compatibility with different infusion solution was determined by spectrophotometry, and the effects of pH, osmotic pressure, NaCl- and glucose on hemolysis were determined by spectrophotometry. Results: when puerarin injection was mixed with different infusion solution, the hemolysis rate of the same concentration and the same incubation time were significantly different. However, there was no significant change in osmotic pressure. Glucose molecules could significantly affect the hemolysis rate. Conclusion: there is significant difference in pH value between puerarin injection and different infusion solution, osmotic pressure is not the factor of hemolysis difference, puerarin injection is mixed with 0.9% sodium chloride injection and 5% glucose injection. The difference in membrane permeability of erythrocytes to solute components Na + Cl- and glucose may be the main cause of the difference in hemolysis.
【作者单位】：中国药科大学临床药学教研室;
【基金】：国家自然科学基金(编号:81073145)
【分类号】：R969.2

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