基于表面自由能的粒子设计研究进展

发布时间：2018-07-02 10:10

本文选题：表面自由能 + 粒子设计　；参考：《中国药学杂志》2017年14期

【摘要】：随着对表面自由能研究的深入,利用粒子设计过程表面自由能相关参数的变化,探索出许多基于表面自由能性质的粒子设计系统。物料经粒子设计后改变理化属性,表面自由能产生了新的变化。因此,可通过表面自由能性质变化特征指导粒子设计过程。笔者综述了表面自由能性质在微粉化、粒子改性、混合、包衣、制丸与制粒等粒子设计过程的应用。通过表面自由能相关参数构建了色散力-极性力模型和黏附-凝聚模型,并阐述了色散力-极性力模型和黏附-凝聚模型在粒子设计中的应用。
[Abstract]:With the further study of surface free energy, many particle design systems based on surface free energy properties have been explored by using the variation of surface free energy parameters in particle design process. After particle design, the physical and chemical properties of materials are changed, and the surface free energy changes. Therefore, the particle design process can be guided by the change characteristics of surface free energy properties. The applications of surface free energy properties in particle design such as micro-pulverization, particle modification, mixing, coating, pelletizing and granulation are reviewed in this paper. The dispersion force-polarity force model and the adhesion-condensation model are constructed through the surface free energy correlation parameters, and the applications of the dispersion-polarity force model and the adhesion-condensation model in particle design are described.
【作者单位】：上海中医药大学中药现代制剂技术教育部工程研究中心;上海中医药大学中药学院;
【基金】：国家自然科学基金资助项目(81403110) 上海市科委资助项目(15DZ2292000)
【分类号】：R943

【共引文献】