甘草次酸脂化乳的质量评价指标探讨

发布时间：2018-07-05 02:31

  本文选题：甘草次酸脂化乳 + 质量评价　； 参考：《中国药房》2017年06期

【摘要】：目的:为甘草次酸脂化乳的质量评价提供参考指标。方法:采用冷冻透射电子显微镜检测甘草次酸脂化乳粒子形态,激光纳米粒度仪测定其粒径、多分散系数(PDI)及电位情况;采用超高效液相色谱法测定其中有效成分甘草次酸的载药量;在30℃下放置10 d考察该制剂的稳定性。结果:制备的甘草次酸脂化乳轮廓清晰、结构完整、呈类圆形、排列紧密;平均粒径为(245.2±4.29)nm,PDI为(0.054±0.01),平均电位为(-6.25±0.54)m V;甘草次酸的载药量平均值为(1.25±0.09)mg/m L;质量浓度为0.82 mg/m L的样品在10 d内稳定性良好。结论:粒径、电位、载药量、稳定性可作为甘草次酸脂化乳的评价指标。
[Abstract]:Objective: to provide a reference index for the quality evaluation of liquorice fatty milk. Methods: the morphology of lipidized glycyrrhetinic acid emulsion was detected by freezing transmission electron microscope. The particle size, polydispersity coefficient (PDI) and potential were measured by laser nanocrystalline analyzer. The drug loading capacity of glycyrrhetinic acid was determined by ultra-high performance liquid chromatography, and the stability of the preparation was investigated at 30 鈩，

本文编号：2098534